PDF(Pubmed)
Abstract：
UNASSIGNED: The iStent is a popular device designed for glaucoma treatment, functioning by creating an artificial fluid pathway in the trabecular meshwork (TM) to drain aqueous humor. The assessment of iStent implantation surgery is clinically important. However, current tools offer limited information.
UNASSIGNED: We aim to develop innovative assessment strategies for iStent implantation using optical coherence tomography (OCT) to evaluate the position and orientation of the iStent and its biomechanical impact on outflow system dynamics.
UNASSIGNED: We examined four iStents in the two eyes of a glaucoma patient. Three-dimensional (3D) OCT structural imaging was conducted for each iStent, and a semi-automated algorithm was developed for iStent segmentation and visualization, allowing precise measurement of position and orientation. In addition, phase-sensitive OCT (PhS-OCT) imaging was introduced to measure the biomechanical impact of the iStent on the outflow system quantified by cumulative displacement (CDisp) of pulse-dependent trabecular TM motion.
UNASSIGNED: The 3D structural image processed by our algorithm definitively resolved the position and orientation of the iStent in the anterior segment, revealing substantial variations in relevant parameters. PhS-OCT imaging demonstrated significantly higher CDisp in the regions between two iStents compared to locations distant from the iStents in both OD ( p = 0.0075 ) and OS ( p = 0.0437 ).
UNASSIGNED: Our proposed structural imaging technique improved the characterization of the iStent\'s placement. The imaging results revealed inherent challenges in achieving precise control of iStent insertion. Furthermore, PhS-OCT imaging unveiled potential biomechanical alterations induced by the iStent. This unique methodology shows potential as a valuable clinical tool for evaluating iStent implantation.
UNASSIGNED: We aim to develop innovative assessment strategies for iStent implantation using optical coherence tomography (OCT) to evaluate the position and orientation of the iStent and its biomechanical impact on outflow system dynamics.
UNASSIGNED: We examined four iStents in the two eyes of a glaucoma patient. Three-dimensional (3D) OCT structural imaging was conducted for each iStent, and a semi-automated algorithm was developed for iStent segmentation and visualization, allowing precise measurement of position and orientation. In addition, phase-sensitive OCT (PhS-OCT) imaging was introduced to measure the biomechanical impact of the iStent on the outflow system quantified by cumulative displacement (CDisp) of pulse-dependent trabecular TM motion.
UNASSIGNED: The 3D structural image processed by our algorithm definitively resolved the position and orientation of the iStent in the anterior segment, revealing substantial variations in relevant parameters. PhS-OCT imaging demonstrated significantly higher CDisp in the regions between two iStents compared to locations distant from the iStents in both OD ( p = 0.0075 ) and OS ( p = 0.0437 ).
UNASSIGNED: Our proposed structural imaging technique improved the characterization of the iStent\'s placement. The imaging results revealed inherent challenges in achieving precise control of iStent insertion. Furthermore, PhS-OCT imaging unveiled potential biomechanical alterations induced by the iStent. This unique methodology shows potential as a valuable clinical tool for evaluating iStent implantation.
摘要：
■iStent是一种用于青光眼治疗的流行设备，通过在小梁网（TM）中创建人工流体通道来排出房水。iStent植入手术的评估在临床上很重要。然而,当前工具提供的信息有限。
■我们旨在使用光学相干断层扫描（OCT）为iStent植入开发创新的评估策略，以评估iStent的位置和方向及其对流出系统动力学的生物力学影响。
■我们检查了青光眼患者两只眼睛中的四个支架。对每个iStent进行三维(3D)OCT结构成像,并开发了一种用于iStent分割和可视化的半自动算法，允许位置和方向的精确测量。此外,引入了相敏OCT（PhS-OCT）成像，以测量iStent对流出系统的生物力学影响，该影响通过脉冲依赖性小梁TM运动的累积位移（CDisp）量化。
■通过我们的算法处理的3D结构图像最终解决了iStent在眼前段的位置和方向，揭示了相关参数的实质性变化。在OD(p=0.0075)和OS(p=0.0437)中,与远离iStents的位置相比,PhS-OCT成像在两个iStents之间的区域中显示出显著更高的CDisp。
■我们提出的结构成像技术改进了iStent放置的表征。成像结果揭示了实现iStent插入的精确控制的固有挑战。此外，PhS-OCT成像揭示了iStent引起的潜在生物力学改变。这种独特的方法显示出作为评估iStent植入的有价值的临床工具的潜力。
■我们旨在使用光学相干断层扫描（OCT）为iStent植入开发创新的评估策略，以评估iStent的位置和方向及其对流出系统动力学的生物力学影响。
■我们检查了青光眼患者两只眼睛中的四个支架。对每个iStent进行三维(3D)OCT结构成像,并开发了一种用于iStent分割和可视化的半自动算法，允许位置和方向的精确测量。此外,引入了相敏OCT（PhS-OCT）成像，以测量iStent对流出系统的生物力学影响，该影响通过脉冲依赖性小梁TM运动的累积位移（CDisp）量化。
■通过我们的算法处理的3D结构图像最终解决了iStent在眼前段的位置和方向，揭示了相关参数的实质性变化。在OD(p=0.0075)和OS(p=0.0437)中,与远离iStents的位置相比,PhS-OCT成像在两个iStents之间的区域中显示出显著更高的CDisp。
■我们提出的结构成像技术改进了iStent放置的表征。成像结果揭示了实现iStent插入的精确控制的固有挑战。此外，PhS-OCT成像揭示了iStent引起的潜在生物力学改变。这种独特的方法显示出作为评估iStent植入的有价值的临床工具的潜力。
