Abstract:
The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.
摘要:
肌萎缩侧索硬化症(ALS)的生物标志物的鉴定是疾病研究中的核心问题。在最近的一篇文章中,Chatterjee等人。表明,血液细胞外囊泡(EV)与高水平的反式反应DNA结合蛋白43(TDP-43)准确区分ALS患者与对照组,并与疾病严重程度相关,为早期诊断和监测提供有前途的生物标志物。