Abstract：
The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.
摘要：
肌萎缩侧索硬化症（ALS）的生物标志物的鉴定是疾病研究中的核心问题。在最近的一篇文章中，Chatterjee等人。表明，血液细胞外囊泡（EV）与高水平的反式反应DNA结合蛋白43（TDP-43）准确区分ALS患者与对照组，并与疾病严重程度相关，为早期诊断和监测提供有前途的生物标志物。
