Abstract：
This study assessed the effect of serum magnesium levels and their role in the outcome of allogeneic hematopoietic cell transplantation (allo-HSCT) in acute leukemia. Fifty-four patients with acute leukemia who underwent allo-HSCT were divided into two groups according to their serum magnesium levels before transplantation. The results showed that serum magnesium level is an independent factor influencing the prognosis of patients undergoing allo-HSCT. Low magnesium levels were associated with inferior overall survival and event-free survival compared with the associations of high magnesium levels (HR = 0.149; (95% CI: 0.029-0.755 for overall survival; HR = 0.369; 95% CI: 0.144-0.949, p = 0.039 for event-free survival). The competing risk model showed that the cumulative incidence of acute graft-versus-host disease was significantly low in the high magnesium group (p = 0.028). In general, there is a correlation between high magnesium levels and superior outcomes, including less and milder acute graft-versus-host disease, which does not affect cyclosporine-A levels. These findings provide valuable information for identifying the risk of poor prognosis in patients preparing for transplantation.
摘要：
这项研究评估了血清镁水平的影响及其在急性白血病异基因造血细胞移植（allo-HSCT）结果中的作用。54例接受allo-HSCT的急性白血病患者根据移植前的血清镁水平分为两组。结果表明，血清镁水平是影响行allo-HSCT患者预后的独立因素。与高镁水平的相关性相比，低镁水平与低总生存率和无事件生存率相关（HR=0.149；（95％CI：0.029-0.755表示总生存率；HR=0.369；95％CI：0.144-0.949，p=0.039）。竞争风险模型显示，高镁组急性移植物抗宿主病的累积发生率明显较低（p=0.028）。总的来说,高镁水平和优越的结果之间存在相关性，包括更少和更轻的急性移植物抗宿主病，不影响环孢菌素A水平。这些发现为确定准备移植的患者预后不良的风险提供了有价值的信息。
