Abstract：
The putamen has been proposed to play a critical role in the development of obsessive-compulsive disorder (OCD). The primary objective of this study was to examine the resting-state regional activity and functional connectivity patterns of the putamen in individuals diagnosed with OCD. To achieve this, we employed resting-state functional magnetic resonance imaging (rs-fMRI) to collect data from a sample of 45 OCD patients and 53 healthy control participants. We aimed to use the regional amplitude of low-frequency fluctuation (ALFF) analysis to generate the ROI masks of the putamen and then conduct the whole brain functional connectivity of the putamen in individuals with OCD. Compared to controls, the OCD group demonstrated decreased ALFF in bilateral putamen. The right putamen also displayed decreased FC with the left putamen extending to the inferior frontal gyrus (IFG), bilateral precuneus extending to calcarine, the right middle occipital cortex extending to the right middle temporal cortex, and the left middle occipital gyrus. The decreased connectivity between the right putamen and the left IFG was negatively correlated with Yale-Brown Obsessive Compulsive scale (Y-BOCS) Obsession Scores. This study aimed to reveal the putamen changes in resting-state activity and connectivity in OCD patients, highlighting the significance of aberrant ALFF/FC of the putamen is a key characteristic of OCD.
摘要：
已提出壳核在强迫症（OCD）的发展中起关键作用。这项研究的主要目的是检查被诊断为OCD的个体中壳核的静息状态区域活动和功能连接模式。为了实现这一点，我们采用静息态功能磁共振成像(rs-fMRI)从45例OCD患者和53例健康对照参与者的样本中收集数据.我们旨在使用低频波动（ALFF）分析的区域振幅来生成壳核的ROI掩模，然后在OCD患者中进行壳核的全脑功能连接。与对照组相比，强迫症组显示双侧壳核ALFF降低。右壳核也显示出FC降低，左壳核延伸到额下回（IFG），双侧前突延伸到钙，右中枕骨皮质延伸到右中颞叶皮质，和左枕中回.右壳核和左IFG之间的连通性降低与耶鲁-布朗强迫症量表（Y-BOCS）强迫症得分呈负相关。这项研究旨在揭示强迫症患者静息状态活动和连通性的壳核变化。强调壳核异常ALFF/FC的重要性是强迫症的关键特征。
