关键词: Antitubercular drugs DOTS New Delhi Pulmonary tuberculosis Treatment adherence

Mesh : Humans Tuberculosis, Pulmonary / drug therapy psychology Female Adult India Male Cross-Sectional Studies Medication Adherence / statistics & numerical data psychology Antitubercular Agents / therapeutic use Directly Observed Therapy Middle Aged Young Adult Surveys and Questionnaires Reminder Systems

来  源:   DOI:10.1016/j.ijtb.2023.08.006

Abstract:
BACKGROUND: TB is treated with a six-month course of four antimicrobial drugs, and nearly all cases of TB can be cured if the medications are given and taken correctly. Due to its prolong treatment plans, there can be reasons associated with non-adherence to treatment by TB patients. Hence, the present study aimed to explore the factors associated with medication adherence among TB patients.
METHODS: A cross-sectional descriptive survey was conducted among adult pulmonary tuberculosis patients enrolled under RNTCP (now NTEP) in New Delhi among 27 functional RNTCP districts. Around 200 TB patients who are enrolled in the Nikshay App and are also on treatment were considered. A structured questionnaire was prepared for the interview guide. Analysis was done using bivariate analysis, chi-square tests, and Fisher\'s exact tests.
RESULTS: Among the total participants, 173 (86.5%) were adherent and the remaining 27 (13.5%) participants were non-adherent. The majority of the participants (91%) said they were able to follow the routine to the DOTS center, and 9% said they find it difficult to report to the DOTS center as per their schedule. Only 12.35% of non-adherent participants were seen among those who get regular reminders from their families to take medicines, as compared to 18.42% among those who did not get regular reminders from their families. More than one-fourth of the participants (25.9%) who report not getting necessary motivation from healthcare providers were non-adherent. Motivation by healthcare workers to follow drug schedules was found statistically significant to treatment compliance with a P-value of 0.0422.
CONCLUSIONS: TB is a curable disease; this belief has turned out to be a motivational factor for patients suffering from this disease. Studies have shown that faith in the efficacy of treatment helps adherence to TB treatment while other studies describe how patient adherence was adversely affected by the belief that TB is incurable or the treatment is inefficient or that alternative treatment such as traditional medicine is better.
摘要:
背景:结核病治疗六个月的四种抗菌药物,如果正确给予和服用药物,几乎所有的结核病病例都可以治愈。由于其延长的治疗计划,可能有与结核病患者不坚持治疗相关的原因.因此,本研究旨在探讨结核病患者服药依从性的相关因素.
方法:对新德里27个功能性RNTCP地区的RNTCP(现为NTEP)注册的成年肺结核患者进行了横断面描述性调查。考虑了约200名在NikshayApp中注册并正在接受治疗的结核病患者。为面试指南准备了一份结构化问卷。使用双变量分析进行分析,卡方检验,和费希尔的精确测试。
结果:在所有参与者中,173名(86.5%)为粘附者,其余27名(13.5%)为非粘附者。大多数参与者(91%)表示他们能够按照常规前往DOTS中心,9%的人说他们很难按照他们的时间表向DOTS中心报告。只有12.35%的非坚持参与者在那些定期收到家人的提醒服用药物的人中看到,相比之下,在那些没有得到家人定期提醒的人中,这一比例为18.42%。超过四分之一(25.9%)的参与者报告没有从医疗保健提供者那里获得必要的动力,他们没有坚持。发现医护人员遵循药物时间表的动机对治疗依从性具有统计学意义,P值为0.0422。
结论:结核病是一种可治愈的疾病;这种信念已成为患有这种疾病的患者的动机因素。研究表明,对治疗效果的信念有助于坚持结核病治疗,而其他研究则描述了结核病无法治愈或治疗效率低下或传统医学等替代疗法更好的信念如何对患者的依从性产生不利影响。
公众号