PDF(Pubmed)
Abstract：
Species belonging to the genus Salvia, Lamiaceae, have been deeply involved in the folk medicine of different nations since ancient times. Lilac sage, or Salvia verticillata L. (S. verticillata) is a less studied species from the genus. However, it seems to have a prominent potential for the future drug discovery strategies of novel phytopharmaceuticals. This review aims to summarise the data on the biological activity and the phytochemical profile of extracts and essential oils derived from S. verticillata. This review is based on data from 57 in vitro and in vivo studies. The chemical profile of S. verticillata includes different synergic compounds like phenolic acids, flavonoids, terpenes, and salvianolic acids. Although some small amounts of salvianolic acid B were found in S. verticillata extracts, the major compound among the salvianolic acids is salvianolic acid C, a compound associated with the potential for improving liver fibrosis, cardio- and hepatoprotection, and the inhibition of SARS-CoV-2 infection. The cannabinoid type 2 receptor agonist β-caryophyllene is one of the major compounds in S. verticillata essential oils. It is a compound with a prominent potential in regenerative medicine, neurology, immunology, and other medical fields. The in vivo and the in vitro studies, regarding S. verticillata highlighted good antioxidant potential, anti-inflammatory, antibacterial, and antifungal activity. S.verticillata was also reported as a potential source of drug candidates for the treatment of neurodegenerative diseases such as Alzheimer\'s disease, because of the inhibitory activity on the acetylcholinesterase. However, the number of studies in this direction is limited.
摘要：
属于丹参属的物种，唇形科，自古以来就深深参与了不同民族的民间医学。丁香鼠尾草,或丹参(S.verticillata）是该属中研究较少的物种。然而,它似乎对新型植物药物的未来药物发现策略具有突出的潜力。这篇综述旨在总结来自S.verticillata的提取物和精油的生物活性和植物化学特征的数据。这篇综述基于57项体外和体内研究的数据。S.verticillata的化学特征包括不同的协同化合物，如酚酸，黄酮类化合物，萜烯,和丹酚酸。虽然一些少量的丹酚酸B被发现在S.verticilata提取物，丹酚酸中的主要化合物是丹酚酸C，一种与改善肝纤维化潜力相关的化合物，心脏和肝脏保护，和抑制SARS-CoV-2感染。大麻素2型受体激动剂β-石竹烯是S.verticilata精油中的主要化合物之一。它是一种在再生医学中具有突出潜力的化合物，神经学,免疫学,和其他医疗领域。体内和体外研究，关于S.verticillata强调了良好的抗氧化潜力，抗炎,抗菌，和抗真菌活性。S.verticillata也被报道为治疗神经退行性疾病如阿尔茨海默病的候选药物的潜在来源，因为对乙酰胆碱酯酶的抑制活性。然而,这方面的研究数量有限。
