PDF(Pubmed)
Abstract：
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal tract (GI), characterized by recurrent episodes of inflammation and tissue destruction. It affects an increasing number of individuals worldwide who suffer from Crohn\'s disease (CD) or ulcerative colitis (UC). Despite substantial advances in understanding the underlying causes of IBD, the available treatments remain restricted and are sometimes accompanied by severe consequences. Consequently, there is an urgent need to study alternate therapeutic options. This review assesses the present drugs, identifies their limitations, and proposes the use of saffron, a natural plant with great therapeutic potential based on preclinical and clinical investigations. Saffron has gained attention for its potential therapeutic benefits in treating various ailments due to its established bioactive compounds possessing antioxidant and anti-inflammatory properties. This review covers how saffron impacts the levels of calprotectin, an inflammatory marker, for various inflammatory responses in multiple diseases including IBD. Data from clinical trials were assessed to determine the efficacy and safety of using saffron to counter inflammation in multiple diseases. Studies have shown that saffron may protect against inflammatory bowel disease (IBD) through several mechanisms by inhibiting pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), reducing oxidative stress through antioxidant effects, enhancing mucosal barrier function by upregulating tight junction proteins, and modulating the gut microbiota composition to promote beneficial bacteria while suppressing pathogenic ones; these combined actions contribute to its therapeutic potential in managing and alleviating the symptoms of IBD. This will enable future research endeavors and expedite the translation of saffron-based interventions into clinical practice as a valuable adjunctive therapy or a potential alternative to conventional treatments, thereby enhancing the quality of life for individuals suffering from inflammatory diseases including IBD.
摘要：
炎症性肠病（IBD）是胃肠道（GI）的慢性炎症性疾病，以反复发作的炎症和组织破坏为特征。它影响全世界越来越多的患有克罗恩病(CD)或溃疡性结肠炎(UC)的个体。尽管在理解IBD的根本原因方面取得了重大进展，可用的治疗方法仍然受到限制，有时会伴有严重后果。因此,迫切需要研究替代治疗方案.这篇综述评估了目前的药物，找出它们的局限性，并建议使用藏红花，一种基于临床前和临床研究的具有巨大治疗潜力的天然植物。藏红花因其具有抗氧化和抗炎特性的已建立的生物活性化合物而在治疗各种疾病方面具有潜在的治疗益处而受到关注。这篇综述涵盖了藏红花如何影响钙卫蛋白的水平，炎症标记物,包括IBD在内的多种疾病中的各种炎症反应。评估来自临床试验的数据以确定使用藏红花在多种疾病中对抗炎症的功效和安全性。研究表明，藏红花可能通过抑制促炎细胞因子（TNF-α，IL-1β,和IL-6），通过抗氧化作用减少氧化应激，通过上调紧密连接蛋白增强粘膜屏障功能，和调节肠道微生物组成，以促进有益细菌，同时抑制致病细菌;这些联合作用有助于其在管理和缓解IBD症状方面的治疗潜力。这将使未来的研究努力，并加快将藏红花为基础的干预措施转化为临床实践，作为有价值的辅助治疗或传统治疗的潜在替代方案。从而提高患有炎性疾病(包括IBD)的个体的生活质量。
