PDF(Pubmed)
Abstract：
Background and Objectives: In adults, 150 to 300 min a week of moderate-intensity physical activity is the recommended daily level to maintain or improve fitness. In subjects with chronic obstructive pulmonary disease (COPD), reductions in daily physical activity (DPA) amounts are related to clinically significant outcomes. In this study, we ascertain whether or not COPD patients, when clustered into active (DPA ≥ 30 min a day, 5 days a week) and inactive (DPA < 30 min a day, 5 days a week), may differ in exercise capacity, as assessed by a cardiopulmonary exercise test (CPET). Materials and Methods: A large sample of clinically stable COPD patients was retrospectively recruited and then underwent spirometry and an incremental ramp protocol 5-15 watts/min CPET. DPA was assessed by a questionnaire. Results: A total of 83 (female 25%, age range 41-85 y) active and 131 (female 31%, age range 49-83 y) inactive participants were enrolled. They were similar in age, sex distribution, body mass index (BMI) and in spirometry. The two groups were significantly different in dyspnea on exertion, as assessed by the modified Medical Research Council (mMRC), and in cardio-metabolic parameters, but not in ventilatory ones, as confirmed by the CPET. Conclusions: COPD patients experiencing physical activity of at least 30 min a day, 5 days a week, showed a greater exercise capacity and an improved cardiovascular response to exercise, when compared to inactive ones. Active and inactive participants did not differ in terms of airflow obstruction severity as well as in dynamic hyperinflation and ventilatory inefficiency during exercise. This study further suggests the benefits of regular physical activity in COPD.
摘要：
背景和目标：在成年人中，每周150至300分钟的中等强度体力活动是维持或改善健身的推荐每日水平。在患有慢性阻塞性肺疾病（COPD）的受试者中，每日体力活动(DPA)量的减少与临床显著结局相关.在这项研究中,我们确定COPD患者是否，当集群为活动时(DPA每天≥30分钟，每周5天)和不活动(DPA每天<30分钟，一周5天),运动能力可能不同，通过心肺运动试验（CPET）评估。材料和方法：回顾性招募了大量临床稳定的COPD患者，然后进行了肺活量测定和5-15瓦/分钟的递增斜坡方案CPET。DPA通过问卷调查进行评估。结果：共83名（女性25％，年龄范围41-85岁)活跃和131岁(女性31%，年龄范围49-83岁)不活动的参与者被纳入。他们年龄相似，性别分布，体重指数（BMI）和肺活量测定。两组在劳力性呼吸困难方面有显著差异,根据修改后的医学研究理事会(MMRC)的评估，在心脏代谢参数方面，但不是在通气的，经CPET确认。结论：COPD患者每天至少30分钟的体力活动，一周五天,表现出更大的运动能力和改善的心血管对运动的反应，与不活跃的相比。活跃和不活跃的参与者在气流阻塞的严重程度以及运动过程中的动态过度充气和通气效率低下方面没有差异。这项研究进一步表明，定期体育锻炼对COPD的益处。
