Abstract：
To analyse clinical, laboratory, and epidemiological data of a cohort of patients with acute hepatitis E treated at the Clinic of Infectology and Travel Medicine (CITM) in Košice.
Retrospective analysis of hospital information system data on patients diagnosed with acute hepatitis E who were examined or hospitalized at CITM in 2015-2023. Statistical evaluation of the available data with a focus on epidemiology, course, and complications.
The cohort consisted of 62 patients. Fifty-eight percent were male. The mean age was 56 years. Seventy-four percent of patients were hospitalized, with a mean length of hospital stay of 10 days. The most common clinical manifestation was jaundice (in 40% of patients). Six patients had stool HEV RNA testing and all were confirmed to have genotype 3. In 5% of patients, the infection was classified as imported (they did not have HEV RNA tested), and 95% of cases were autochthonous. A history of contact with an HEV infected person was reported by 26% of patients. A history of preexisting liver disease was noted in 13% of patients who were confirmed with higher bilirubin, GMT, and ammonia levels. No statistically significant differences were found for patients with a history of immune deficiency. One patient with preexisting liver disease developed fulminant infection resulting in death. Four hepatitis E patients with neurological symptoms had lower bilirubin levels.
The study cohort included predominantly older men. Genotype 3 was confirmed in all patients who underwent HEV RNA testing. Higher bilirubin, ammonia, and GMT levels were confirmed in patients with preexisting liver disease. Patients with neurological complications had lower bilirubin levels. One patient with preexisting liver disease died.
Retrospective analysis of hospital information system data on patients diagnosed with acute hepatitis E who were examined or hospitalized at CITM in 2015-2023. Statistical evaluation of the available data with a focus on epidemiology, course, and complications.
The cohort consisted of 62 patients. Fifty-eight percent were male. The mean age was 56 years. Seventy-four percent of patients were hospitalized, with a mean length of hospital stay of 10 days. The most common clinical manifestation was jaundice (in 40% of patients). Six patients had stool HEV RNA testing and all were confirmed to have genotype 3. In 5% of patients, the infection was classified as imported (they did not have HEV RNA tested), and 95% of cases were autochthonous. A history of contact with an HEV infected person was reported by 26% of patients. A history of preexisting liver disease was noted in 13% of patients who were confirmed with higher bilirubin, GMT, and ammonia levels. No statistically significant differences were found for patients with a history of immune deficiency. One patient with preexisting liver disease developed fulminant infection resulting in death. Four hepatitis E patients with neurological symptoms had lower bilirubin levels.
The study cohort included predominantly older men. Genotype 3 was confirmed in all patients who underwent HEV RNA testing. Higher bilirubin, ammonia, and GMT levels were confirmed in patients with preexisting liver disease. Patients with neurological complications had lower bilirubin levels. One patient with preexisting liver disease died.
摘要：
目的：分析临床，实验室,以及在科希策的传染病学和旅行医学诊所（CITM）治疗的急性戊型肝炎患者队列的流行病学数据。
方法：回顾性分析2015-2023年诊断为急性戊型肝炎的患者的医院信息系统数据。对现有数据进行统计评估，重点是流行病学，当然,和并发症。
结果：队列包括62名患者。58%是男性。平均年龄为56岁。百分之七十四的病人住院,平均住院时间为10天。最常见的临床表现是黄疸（40％的患者）。6名患者进行了粪便HEVRNA检测，所有患者均被确认为基因型3。在5%的患者中，感染被归类为进口（他们没有HEVRNA测试），95%的病例是本地病例。26%的患者报告了与HEV感染者的接触史。已存在的肝脏疾病的病史被记录在13％的患者谁被证实有较高的胆红素，GMT,和氨含量。对于有免疫缺陷病史的患者，没有发现统计学上的显着差异。一名先前存在肝病的患者发生暴发性感染，导致死亡。四名有神经系统症状的戊型肝炎患者的胆红素水平较低。
结论：研究队列主要包括老年男性。在所有接受HEVRNA检测的患者中确认了基因型3。胆红素较高,氨,和GMT水平在先前存在的肝病患者中得到证实。神经系统并发症患者的胆红素水平较低。一名先前存在肝病的患者死亡。
方法：回顾性分析2015-2023年诊断为急性戊型肝炎的患者的医院信息系统数据。对现有数据进行统计评估，重点是流行病学，当然,和并发症。
结果：队列包括62名患者。58%是男性。平均年龄为56岁。百分之七十四的病人住院,平均住院时间为10天。最常见的临床表现是黄疸（40％的患者）。6名患者进行了粪便HEVRNA检测，所有患者均被确认为基因型3。在5%的患者中，感染被归类为进口（他们没有HEVRNA测试），95%的病例是本地病例。26%的患者报告了与HEV感染者的接触史。已存在的肝脏疾病的病史被记录在13％的患者谁被证实有较高的胆红素，GMT,和氨含量。对于有免疫缺陷病史的患者，没有发现统计学上的显着差异。一名先前存在肝病的患者发生暴发性感染，导致死亡。四名有神经系统症状的戊型肝炎患者的胆红素水平较低。
结论：研究队列主要包括老年男性。在所有接受HEVRNA检测的患者中确认了基因型3。胆红素较高,氨,和GMT水平在先前存在的肝病患者中得到证实。神经系统并发症患者的胆红素水平较低。一名先前存在肝病的患者死亡。
