Abstract：
This review rigorously assesses the burgeoning research into the role of polyphenols in modulating mitophagy, an essential cellular mechanism for the targeted removal of impaired mitochondria. These natural compounds, known for their low toxicity, are underscored for their potential in therapeutic strategies against a diverse array of diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply into the molecular mechanisms whereby polyphenols promote mitophagy, particularly by influencing crucial signaling pathways and transcriptional regulators, including the phosphatase and tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin and forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include the neuroprotective properties of resveratrol and curcumin, which affect both autophagic pathways and mitochondrial dynamics, and the pioneering integration of polyphenols with other natural substances to amplify therapeutic effectiveness. Furthermore, the review confronts the issue of polyphenol bioavailability and emphasizes the imperative for clinical trials to corroborate their therapeutic viability. By delivering an exhaustive synthesis of contemporary insights and recent advancements in polyphenol and mitophagy research, this review endeavors to catalyze additional research and foster the creation of innovative therapeutic modalities that exploit the distinctive attributes of polyphenols to manage and prevent disease.
摘要：
这篇综述严格评估了多酚在调节线粒体自噬中的作用的新兴研究，靶向去除受损线粒体的重要细胞机制。这些天然化合物，以其低毒性而闻名，强调了它们在针对各种疾病的治疗策略中的潜力，比如神经退行性疾病，心血管,和肌肉骨骼疾病。该分析深入到多酚促进线粒体自噬的分子机制，特别是通过影响关键的信号通路和转录调节因子，包括磷酸酶和张力蛋白同源物（PTEN）诱导的推定激酶1（PINK1）/parkin和叉头盒O3（FOXO3a）途径。值得注意的发现包括白藜芦醇和姜黄素的神经保护特性，影响自噬途径和线粒体动力学，以及多酚与其他天然物质的开创性整合，以增强治疗效果。此外，该综述面临多酚生物利用度的问题，并强调临床试验证实其治疗可行性的必要性。通过提供当代见解和多酚和线粒体自噬研究的最新进展的详尽综合，这篇综述致力于促进更多的研究，并促进创新的治疗方式的创造，利用多酚的独特属性来管理和预防疾病。
