分离和全合成 PM170453 , 一种从 Lyngbya sp 。
关键词: Lyngbya PD-1/PD-L1 inhibition cyanobacteria cyclic depsipeptide cytotoxicity isolation structure elucidation total synthesis
Mesh : Depsipeptides / pharmacology isolation & purification chemistry chemical synthesis Humans Cyanobacteria / chemistry Cell Line, Tumor Antineoplastic Agents / pharmacology isolation & purification chemistry chemical synthesis Aquatic Organisms B7-H1 Antigen / antagonists & inhibitors Pacific Ocean Peptides, Cyclic / pharmacology chemistry isolation & purification
来 源:
DOI:10.3390/md22070303
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