PDF(Pubmed)
Abstract：
Benzodiazepine (BZD) dependence poses a significant challenge in mental health, prompting the exploration of treatments like repetitive transcranial magnetic stimulation (rTMS). This research aims to assess the impact of rTMS on alleviating symptoms of BZD dependence. A randomized control trial was employed to study 40 BZD-dependent inpatients. Their symptoms were quantified using the Hamilton Anxiety Rating Scale (HAMA), Montgomery-Åsberg Depression Rating Scale (MADRS) and Pittsburgh Sleep Quality Index (PSQI). Participants were divided into a conventional treatment group (daily diazepam with gradual tapering) with supportive psychotherapy and another group receiving the same treatment supplemented with rTMS (five weekly sessions for 2 weeks). Significant improvements were observed in both groups over baseline in MADRS, HAMA and PSQI scores at the 2nd, 4th, 8th and 12th week assessments (p < 0.05). The group receiving rTMS in addition to conventional treatment exhibited superior improvements in all measures at the 8th and 12th weeks. The addition of rTMS to conventional treatment methods for BZD dependence significantly betters the recovery in terms of depression, anxiety and sleep quality, highlighting the role of rTMS as an effective adjunct therapy.
摘要：
苯二氮卓（BZD）依赖对心理健康构成重大挑战，提示探索重复经颅磁刺激（rTMS）等治疗方法。本研究旨在评估rTMS对缓解BZD依赖症状的影响。采用随机对照试验研究了40例BZD依赖性住院患者。他们的症状使用汉密尔顿焦虑量表（HAMA）进行量化，蒙哥马利-奥斯贝格抑郁量表(MADRS)和匹兹堡睡眠质量指数(PSQI)。参与者被分为常规治疗组（每日地西泮逐渐减少）和支持性心理治疗，另一组接受相同的治疗并补充rTMS（每周五次，共2周）。两组在MADRS的基线上观察到显著改善，HAMA和PSQI得分第二，第四，第8周和第12周评估(p<0.05)。除常规治疗外，接受rTMS的组在第8周和第12周的所有措施中均表现出优异的改善。在BZD依赖的常规治疗方法中添加rTMS可显着改善抑郁症的恢复，焦虑和睡眠质量，强调rTMS作为一种有效的辅助疗法的作用。
