PDF(Pubmed)
Abstract：
OBJECTIVE: We aim to present a case of disseminated fusariosis that occurred in the setting of immunosuppression and presented with bilateral endogenous endophthalmitis, along with a literature review of Fusarium endophthalmitis, highlighting management strategies.
METHODS: A 70-year-old male with acute myeloid leukemia who had recently undergone a bone marrow transplant noted bilateral floaters and decreased vision. He was found to have bilateral Fusarium endophthalmitis, with subsequent evidence of fungemia and fusariosis in his skin and joints. Despite aggressive local and systemic treatment, he succumbed to the disease. Endophthalmitis was initially stabilized with pars plana vitrectomy and intravitreal amphotericin and voriconazole until the patient transitioned to comfort measures. A review of 31 cases demonstrates that outcomes are poor and that the disease must be treated aggressively, often both systemically and surgically.
CONCLUSIONS: This case highlights the recalcitrance of Fusarium bacteremia and Fusarium endophthalmitis.
METHODS: A 70-year-old male with acute myeloid leukemia who had recently undergone a bone marrow transplant noted bilateral floaters and decreased vision. He was found to have bilateral Fusarium endophthalmitis, with subsequent evidence of fungemia and fusariosis in his skin and joints. Despite aggressive local and systemic treatment, he succumbed to the disease. Endophthalmitis was initially stabilized with pars plana vitrectomy and intravitreal amphotericin and voriconazole until the patient transitioned to comfort measures. A review of 31 cases demonstrates that outcomes are poor and that the disease must be treated aggressively, often both systemically and surgically.
CONCLUSIONS: This case highlights the recalcitrance of Fusarium bacteremia and Fusarium endophthalmitis.
摘要：
目的：我们的目的是介绍一例发生在免疫抑制环境中并表现为双侧内源性眼内炎的播散性镰刀菌病，以及镰刀菌眼内炎的文献综述，突出管理策略。
方法：一名患有急性髓细胞性白血病的70岁男性，最近接受了骨髓移植，发现双侧漂浮物和视力下降。他被发现患有双侧镰刀菌眼内炎，随后在他的皮肤和关节中发现了真菌血症和镰刀菌病。尽管积极的局部和全身治疗，他死于疾病。眼内炎最初通过平坦部玻璃体切除术和玻璃体内注射两性霉素和伏立康唑来稳定，直到患者过渡到舒适措施。对31例病例的审查表明，结果很差，必须积极治疗该疾病，通常是全身和手术。
结论：该病例突出显示镰刀菌菌血症和镰刀菌眼内炎的顽抗。
方法：一名患有急性髓细胞性白血病的70岁男性，最近接受了骨髓移植，发现双侧漂浮物和视力下降。他被发现患有双侧镰刀菌眼内炎，随后在他的皮肤和关节中发现了真菌血症和镰刀菌病。尽管积极的局部和全身治疗，他死于疾病。眼内炎最初通过平坦部玻璃体切除术和玻璃体内注射两性霉素和伏立康唑来稳定，直到患者过渡到舒适措施。对31例病例的审查表明，结果很差，必须积极治疗该疾病，通常是全身和手术。
结论：该病例突出显示镰刀菌菌血症和镰刀菌眼内炎的顽抗。
