关键词: Bleomycin Ranula Sclerotherapy Sublingual Gland

Mesh : Bleomycin / administration & dosage therapeutic use Humans Ranula Sclerotherapy / methods Female Adult Male Injections, Intralesional Middle Aged Adolescent Sclerosing Solutions / therapeutic use administration & dosage Young Adult Treatment Outcome Aged Child Sublingual Gland

来  源:   DOI:10.1186/s12903-024-04633-8   PDF(Pubmed)

Abstract:
Ranula is a mucous cyst that occurs in the sublingual gland (SLG) in the floor of the mouth. It can be classified into two types based on origins: One is the the lesser sublingual gland (LSLG) in the anterior segment and the Rivini duct, which is connected to it, and the other is the greater sublingual gland (GSLG) in the posterior segment. Because of the anatomical characteristics, surgical resection of the cysts carries the risk of damaging adjacent tissues and has a high recurrence rate. Intralesional injection of sclerotherapy may be a better alternative treatment. We summarized 65 cases of ranula treated with intralesional injections of bleomycin(BML). According to the origin of the ranula, 60 cases were from the LSLG and the Rivini duct, and 5 cases were from the GSLG. The results showed that 60 cases of ranula from LSLG and Rivini ducts were 100% cured during the follow-up period. The median number of injections for all patients was 1.16. All 5 cases of ranula from the GSLG did not wholly recover. This study confirmed that BLM intralesional injection is a safe and effective treatment modality for cysts from LSLG or the ducts of Rivini rather than GSLG. Therefore, before treatment, it is necessary to determine the type and origin of the cyst by characterizing its morphology to ensure the effectiveness of the treatment.
摘要:
Rusula是一种粘液囊肿,发生在口底的舌下腺(SLG)中。根据起源可以分为两种类型:一种是前段和Rivini导管中的较小舌下腺(LSLG),与之相连的,另一个是后段的大舌下腺(GSLG)。由于解剖特征,手术切除囊肿有损害邻近组织的风险,并且复发率高。硬化剂的病灶内注射可能是更好的替代疗法。我们总结了65例博莱霉素(BML)病灶内注射治疗的ranula病例。根据ranula的起源,60例来自LSLG和Rivini导管,5例来自GSLG。结果表明,在随访期间,来自LSLG和Rivini导管的ranula的60例治愈了100%。所有患者的中位注射次数为1.16。来自GSLG的所有5例ranula均未完全恢复。这项研究证实,BLM病灶内注射是LSLG或Rivini导管而不是GSLG囊肿的安全有效治疗方式。因此,治疗前,有必要通过表征囊肿的形态来确定囊肿的类型和起源,以确保治疗的有效性。
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