Abstract：
Weed resistance is a critical issue in crop production. Among the known herbicides, 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are crucial for addressing weed resistance. HPPD inhibitors constitute a pivotal aspect of contemporary crop protection strategies. The advantages of these herbicides are their broad weed spectrum, flexible application, and excellent compatibility with other herbicides. They also exhibit satisfactory crop selectivity and low toxicity and are environmentally friendly. An increasing number of new HPPD inhibitors have been designed by combining computer-aided drug design with conventional design approaches. Herein, the molecular design and structural features of innovative HPPD inhibitors are reviewed to guide the development of new HPPD inhibitors possessing an enhanced biological efficacy.
摘要：
杂草抗性是作物生产中的关键问题。在已知的除草剂中，4-羟基苯基丙酮酸双加氧酶（HPPD）抑制剂对于解决杂草抗性至关重要。HPPD抑制剂是当代作物保护策略的关键方面。这些除草剂的优点是其广泛的杂草谱，灵活的应用，以及与其他除草剂的优异相容性。它们还表现出令人满意的作物选择性和低毒性,并且是环境友好的。通过将计算机辅助药物设计与常规设计方法相结合，已经设计了越来越多的新HPPD抑制剂。在这里，综述了创新HPPD抑制剂的分子设计和结构特征，以指导开发具有增强生物学功效的新型HPPD抑制剂。
