METHODS: An analytical cross-sectional study involving women aged 18-45 years was conducted. Microbiological assessments included Ureaplasma and Mycoplasma cultures, as well as human papillomavirus hybrid capture using ecto and endocervix swabs. All tests were two-tailed, and significance was set at p<0.05.
RESULTS: Among 324 women, Ureaplasma prevalence was 17.9%, and Mycoplasma prevalence was 3.1%. The Ureaplasma-positive group exhibited a higher frequency of urinary tract infections (39.1 vs. 19%, p=0.002) and human papillomavirus (39.7 vs. 12.8%, p≤0.001) compared with controls. The Mycoplasma-positive group showed a higher frequency of non-contraceptive use compared with controls (66.2 vs. 30.0%, p=0.036). Abnormal colposcopic findings were more prevalent in the Mycoplasma/Ureaplasma-positive group than in controls (positive: 65% vs. control: 35%, p=0.001). Pap smear findings did not differ between the groups.
CONCLUSIONS: Ureaplasma spp. was associated with urinary tract infections and human papillomavirus, while the presence of Mycoplasma sp. was linked to reduced contraceptive use. When analyzing both pathogens together, a higher frequency of abnormal colposcopic findings was observed, with no difference in cytological findings in the positive group.
方法:进行了一项涉及18-45岁女性的横断面分析研究。微生物学评估包括脲原体和支原体培养物,以及使用ecto和宫颈内膜拭子捕获人乳头瘤病毒杂种。所有测试都是双尾的,并且显著性设定为p<0.05。
结果:在324名女性中,脲原体患病率为17.9%,支原体患病率为3.1%。脲原体阳性组尿路感染的频率更高(39.1vs.19%,p=0.002)和人乳头瘤病毒(39.7vs.12.8%,p≤0.001)与对照组相比。与对照组相比,支原体阳性组的非避孕药具使用频率更高(66.2vs.30.0%,p=0.036)。支原体/脲原体阳性组的阴道镜异常发现比对照组更为普遍(阳性:65%vs.控制:35%,p=0.001)。两组之间的巴氏涂片检查结果没有差异。
结论:脲原体属。与尿路感染和人乳头瘤病毒有关,而支原体的存在。与减少避孕药具的使用有关。当一起分析两种病原体时,观察到阴道镜异常发现的频率更高,阳性组的细胞学结果无差异。