UNASSIGNED: In this systematic review and meta-analysis, an exhaustive search was conducted across multiple databases, including PubMed, Web of Science, Embase, and Medline, CNKI, WanFang, and CQVIP. The literature search was confined to publications released between January 1, 2009, and May 29, 2023. The study focused on collating data pertaining to animal infections under natural conditions and human infection cases reported. Additionally, species names were unified using the National Center for Biotechnology Information (NCBI) database. The notification rate, notification death rate, case fatality rate, and infection rates (or MIR) were assessed for each study with available data. The proportions were pooled using a generalized linear mixed-effects model (GLMM). Meta-regressions were conducted for subgroup analysis. This research has been duly registered with PROSPERO, bearing the registration number CRD42023431010.
UNASSIGNED: We identified 5492 studies from database searches and assessed 238 full-text studies for eligibility, of which 234 studies were included in the meta-analysis. For human infection data, the overall pooled notification rate was 18.93 (95% CI 17.02-21.05) per ten million people, the overall pooled notification deaths rate was 3.49 (95% CI 2.97-4.10) per ten million people, and the overall pooled case fatality rate was 7.80% (95% CI 7.01%-8.69%). There was an increasing trend in notification rate and deaths rate, while the case fatality rate showed a significant decrease globally. Regarding animal infection data, among 94 species tested, 48 species were found to carry positive nucleic acid or antibodies. Out of these, 14 species were classified under Arthropoda, while 34 species fell under Chordata, comprising 27 Mammalia and 7 Aves.
UNASSIGNED: This systematic review and meta-analysis present the latest global report on SFTS. In terms of human infections, notification rates and notification deaths rates are on the rise, while the case fatality rate has significantly decreased. More SFTSV animal hosts have been discovered than before, particularly among birds, indicating a potentially broader transmission range for SFTSV. These findings provide crucial insights for the prevention and control of SFTS on a global scale.
UNASSIGNED: None.
■在本系统综述和荟萃分析中,在多个数据库中进行了详尽的搜索,包括PubMed,WebofScience,Embase,还有Medline,CNKI,万方,还有CQVIP.文献检索仅限于2009年1月1日至2023年5月29日之间发布的出版物。该研究的重点是整理有关自然条件下动物感染和报告的人类感染病例的数据。此外,使用国家生物技术信息中心(NCBI)数据库统一物种名称。通知率,通知死亡率,病死率,和感染率(或MIR)评估每个研究与现有数据。使用广义线性混合效应模型(GLMM)汇集比例。进行Meta回归分析。这项研究已经在PROSPERO注册,轴承注册号为CRD42023431010。
■我们从数据库搜索中确定了5492项研究,并评估了238项全文研究的资格。其中234项研究纳入荟萃分析.对于人类感染数据,总体汇总通知率为每1000万人18.93(95%可信区间17.02-21.05),总体汇总通知死亡率为每1000万人3.49(95%CI2.97-4.10),总体合并病例病死率为7.80%(95%CI7.01%-8.69%).通知率和死亡率有上升趋势,而全球病死率显着下降。关于动物感染数据,在测试的94个物种中,发现48个物种携带阳性核酸或抗体。在这些中,14种被归类为节肢动物,有34个物种属于Chordata,包括27个哺乳动物和7个艾夫.
■本系统综述和荟萃分析提供了有关SFTS的最新全球报告。就人类感染而言,通知率和通知死亡率都在上升,而病死率显著下降。已经发现了比以前更多的SFTSV动物宿主,尤其是在鸟类中,指示SFTSV的潜在更宽的传输范围。这些发现为在全球范围内预防和控制SFTS提供了重要的见解。
■无。