Abstract：
BACKGROUND: Previous studies have reported that patients with depression have significant cognitive impairment. The aim of this study is to comprehensively evaluate the impairment of executive functions in patients with depression and whether the cognitive behavior performance of executive function is association with remission of depressive state after clinical treatment.
METHODS: We used cognitive-behavioral test to evaluate the performance of executive functions of 95 inpatients with depression before hospitalization and conducted two follow-up evaluations of their depression status on the 15th day of hospitalization and approximately 9 months after discharge.
RESULTS: The performance of executive function except the accuracy of inhibition control in patients with depression were significantly worse than that of healthy controls. Multivariate linear regression analysis found that the reaction time of working memory not only had a significant linear relationship with the baseline depression scores of patients with depression, but also had a significant linear relationship with the reduced depression scores after two follow-up visits.
CONCLUSIONS: We only used cognitive-behavioral data as indicators to evaluate the cognitive performances of participants and only measured three components of executive function.
CONCLUSIONS: The reaction time of working memory was a stable and effective predictor of symptom relief in patients with depression after clinical treatment. These results provide initial evidence for working memory to predict the clinical prognosis of inpatients with depression prospectively, which could be further leveraged to improve intervention approaches and analyze the heterogeneity of depression.
METHODS: We used cognitive-behavioral test to evaluate the performance of executive functions of 95 inpatients with depression before hospitalization and conducted two follow-up evaluations of their depression status on the 15th day of hospitalization and approximately 9 months after discharge.
RESULTS: The performance of executive function except the accuracy of inhibition control in patients with depression were significantly worse than that of healthy controls. Multivariate linear regression analysis found that the reaction time of working memory not only had a significant linear relationship with the baseline depression scores of patients with depression, but also had a significant linear relationship with the reduced depression scores after two follow-up visits.
CONCLUSIONS: We only used cognitive-behavioral data as indicators to evaluate the cognitive performances of participants and only measured three components of executive function.
CONCLUSIONS: The reaction time of working memory was a stable and effective predictor of symptom relief in patients with depression after clinical treatment. These results provide initial evidence for working memory to predict the clinical prognosis of inpatients with depression prospectively, which could be further leveraged to improve intervention approaches and analyze the heterogeneity of depression.
摘要：
背景：以前的研究报道，抑郁症患者有明显的认知障碍。本研究旨在综合评价抑郁症患者的执行功能受损情况,以及临床治疗后执行功能的认知行为表现是否与抑郁状态的缓解相关。
方法：我们使用认知行为测验评估了95例住院抑郁症患者住院前的执行功能表现，并在住院第15天和出院后约9个月对其抑郁状态进行了两次随访评估。
结果：抑郁症患者除抑制控制的准确性外，执行功能的表现明显差于健康对照组。多元线性回归分析发现,抑郁症患者的工作记忆反应时间不仅与基线抑郁评分存在显著的线性关系,但与两次随访后抑郁评分降低也有显著的线性关系.
结论：我们仅使用认知行为数据作为评估参与者认知表现的指标，并且仅测量了执行功能的三个组成部分。
结论：工作记忆反应时间是抑郁症患者临床治疗后症状缓解的稳定有效预测指标。这些结果为工作记忆预测抑郁症住院患者的临床预后提供了初步证据。这可以进一步利用改进干预方法和分析抑郁症的异质性。
方法：我们使用认知行为测验评估了95例住院抑郁症患者住院前的执行功能表现，并在住院第15天和出院后约9个月对其抑郁状态进行了两次随访评估。
结果：抑郁症患者除抑制控制的准确性外，执行功能的表现明显差于健康对照组。多元线性回归分析发现,抑郁症患者的工作记忆反应时间不仅与基线抑郁评分存在显著的线性关系,但与两次随访后抑郁评分降低也有显著的线性关系.
结论：我们仅使用认知行为数据作为评估参与者认知表现的指标，并且仅测量了执行功能的三个组成部分。
结论：工作记忆反应时间是抑郁症患者临床治疗后症状缓解的稳定有效预测指标。这些结果为工作记忆预测抑郁症住院患者的临床预后提供了初步证据。这可以进一步利用改进干预方法和分析抑郁症的异质性。
