PDF(Pubmed)
Abstract：
UNASSIGNED: Although global mortality rates in children under 5 years have decreased substantially in the last 30 years, there remain around 2.6 million stillbirths and 2.9 million neonatal deaths each year. The majority of these deaths occur in Africa and South Asia. To reduce perinatal deaths in East Africa, knowledge of the burden, but also the risk factors and causes of perinatal deaths are crucial. To the best of our knowledge, reviews have previously focused on the burden of perinatal deaths; here we aim to synthesize evidence on the burden, causes, and risk factors for perinatal mortality in East Africa.
UNASSIGNED: We will conduct a systematic literature search in Medline, Web of Science, EMBASE, Global Health, SCOPUS, Cochrane Library, CINAHL, HINARI, African Index Medicus, African Journals Online (AJOL), and WHO African Regional Office (AFRO) Library. The study population includes all fetuses and newborns from ≥22 weeks of gestation (birth weight ≥500gm) to 7 days after birth, with reported causes or/and determinants as exposure, and perinatal mortality (stillbirths and/or early neonatal deaths) as an outcome. We will include studies from 2010 to 2022, and to facilitate the inclusion of up-to-date data, we will request recent data from ongoing surveillance in the region. To assess the quality of included studies, we will use the Joanna Briggs Institute quality assessment tool for observational and trial studies. We will analyze the data using STATA version 17 statistical software and assess heterogeneity and publication bias by Higgins\' I 2 and funnel plot, respectively.
UNASSIGNED: This systematic review will search for published studies, and seek unpublished data, on the burden, causes, and risk factors of perinatal mortality in East Africa. Findings will be reported, and gaps in the evidence base identified, with recommendations, with the ultimate aim of reducing perinatal deaths.
UNASSIGNED: PROSPERO-CRD42021291719.
UNASSIGNED: We will conduct a systematic literature search in Medline, Web of Science, EMBASE, Global Health, SCOPUS, Cochrane Library, CINAHL, HINARI, African Index Medicus, African Journals Online (AJOL), and WHO African Regional Office (AFRO) Library. The study population includes all fetuses and newborns from ≥22 weeks of gestation (birth weight ≥500gm) to 7 days after birth, with reported causes or/and determinants as exposure, and perinatal mortality (stillbirths and/or early neonatal deaths) as an outcome. We will include studies from 2010 to 2022, and to facilitate the inclusion of up-to-date data, we will request recent data from ongoing surveillance in the region. To assess the quality of included studies, we will use the Joanna Briggs Institute quality assessment tool for observational and trial studies. We will analyze the data using STATA version 17 statistical software and assess heterogeneity and publication bias by Higgins\' I 2 and funnel plot, respectively.
UNASSIGNED: This systematic review will search for published studies, and seek unpublished data, on the burden, causes, and risk factors of perinatal mortality in East Africa. Findings will be reported, and gaps in the evidence base identified, with recommendations, with the ultimate aim of reducing perinatal deaths.
UNASSIGNED: PROSPERO-CRD42021291719.
摘要：
尽管在过去30年中，全球5岁以下儿童的死亡率大幅下降，每年仍有约260万例死胎和290万新生儿死亡。这些死亡大多数发生在非洲和南亚。为了减少东非的围产期死亡，负担的知识，而且围产期死亡的危险因素和原因也至关重要。据我们所知,以前的评论集中在围产期死亡的负担;在这里，我们旨在综合有关负担的证据，原因,以及东非围产期死亡率的危险因素。
■我们将在Medline进行系统的文献检索，WebofScience,EMBASE,全球卫生,Scopus,科克伦图书馆,CINAHL,Hinari,非洲医学指数，非洲在线期刊（AJOL）世卫组织非洲区域办事处图书馆。研究人群包括妊娠≥22周（出生体重≥500gm）至出生后7天的所有胎儿和新生儿，报告的原因或/和决定因素作为暴露，和围产期死亡率（死产和/或新生儿早期死亡）作为结果。我们将纳入2010年至2022年的研究，并促进纳入最新数据，我们将要求该地区正在进行的监视的最新数据。为了评估纳入研究的质量，我们将使用JoannaBriggs研究所的质量评估工具进行观察性和试验性研究.我们将使用STATA17版统计软件分析数据，并通过Higgins\'I2和漏斗图评估异质性和出版偏倚，分别。
■本系统综述将搜索已发表的研究，寻找未发表的数据，在负担上，原因,以及东非围产期死亡率的危险因素。调查结果将被报告，以及在证据基础上的空白，有建议,最终目标是减少围产期死亡。
■PROSPERO-CRD42021291719。
■我们将在Medline进行系统的文献检索，WebofScience,EMBASE,全球卫生,Scopus,科克伦图书馆,CINAHL,Hinari,非洲医学指数，非洲在线期刊（AJOL）世卫组织非洲区域办事处图书馆。研究人群包括妊娠≥22周（出生体重≥500gm）至出生后7天的所有胎儿和新生儿，报告的原因或/和决定因素作为暴露，和围产期死亡率（死产和/或新生儿早期死亡）作为结果。我们将纳入2010年至2022年的研究，并促进纳入最新数据，我们将要求该地区正在进行的监视的最新数据。为了评估纳入研究的质量，我们将使用JoannaBriggs研究所的质量评估工具进行观察性和试验性研究.我们将使用STATA17版统计软件分析数据，并通过Higgins\'I2和漏斗图评估异质性和出版偏倚，分别。
■本系统综述将搜索已发表的研究，寻找未发表的数据，在负担上，原因,以及东非围产期死亡率的危险因素。调查结果将被报告，以及在证据基础上的空白，有建议,最终目标是减少围产期死亡。
■PROSPERO-CRD42021291719。
