Abstract：
Sensory development is a complex process that can influence physiological and pathological factors. In laterally-eyed mammals, monocular enucleation (ME) during development and the subsequent lack of external sensory stimuli can result in permanent morphological and physiological changes. Malnutrition, especially in early life, also can cause permanent morphofunctional changes due to inadequate nutrient intake in both hemispheres. This study investigated the effects of early (postnatal day 7) ME and malnutrition during the suckling period on cortical excitability in adulthood (110-140 days of life). For this, we compared the speed propagation of cortical spreading depression in the occipital and parietal cortex of malnourished and well-nourished adult rats, previously suckled small-sized litters with three pups (L3/dam) medium-sized litters with six pups (L6/dam), and large-sized litters with twelve pups (L12/dam). The CSD velocity was augmented by the ME in the contralateral side of the removed eye in the parietal and occipital cortex. These findings suggest that visual sensory input deprivation is associated with permanent functional changes in the visual pathways, which can alter cortical excitability and lead to modifications in CSD propagation.
摘要：
感觉发育是一个复杂的过程，可以影响生理和病理因素。在侧眼哺乳动物中，在发育过程中单眼摘除（ME）以及随后缺乏外部感觉刺激会导致永久性的形态和生理变化。营养不良,尤其是在生命的早期,由于两个半球的营养摄入不足，也可能导致永久性形态功能变化。这项研究调查了哺乳期早期（出生后第7天）ME和营养不良对成年期（生命110-140天）皮质兴奋性的影响。为此，我们比较了营养不良和营养良好的成年大鼠的枕骨和顶叶皮质中皮质扩散抑制的速度传播，以前哺乳的小窝有三只幼仔（L3/大坝）的中型窝有六只幼仔（L6/大坝），和12只幼仔的大型垃圾(L12/dam)。在顶叶和枕骨皮质中，切除眼睛的对侧的ME增加了CSD速度。这些发现表明，视觉感觉输入剥夺与视觉通路的永久性功能变化有关，这可以改变皮质兴奋性并导致CSD传播的改变。
