Abstract：
OBJECTIVE: Renal involvement in inflammatory bowel disease is rather uncommon. This study aims to describe the spectrum of renal involvement in pediatric patients with IBD and reduce delay in detection and management.
METHODS: This is a retrospective study of the renal function of all patients, aged <18 years, who have been followed for IBD in our pediatric gastroenterology department from January 2019 till January 2023.
RESULTS: From the 75 IBD patients included in this study 16 % had renal manifestations. The urinalysis revealed proteinuria in 7 patients, proteinuria and hematuria in 3 and proteinuria and glycosuria in 2 patients. All 12 patients with abnormal urinalysis underwent further investigation in order to determine the cause of renal damage and the results are as follows: 2 patients had glomerulonephritis and in other 2 patients renal damage was due to medication adverse effect, 1 had pyelonephritis in combination with chronic active tubulointerstitial nephritis and another 1 had thin basement membrane disease. Three patients had IBD-related dependent renal involvement and 1 resulted in chronic renal failure due to amyloidosis.
CONCLUSIONS: It is important for all clinicians to be aware of the possibility of renal manifestations in IBD patients for the early diagnosis and prevention of these manifestations and complications.
METHODS: This is a retrospective study of the renal function of all patients, aged <18 years, who have been followed for IBD in our pediatric gastroenterology department from January 2019 till January 2023.
RESULTS: From the 75 IBD patients included in this study 16 % had renal manifestations. The urinalysis revealed proteinuria in 7 patients, proteinuria and hematuria in 3 and proteinuria and glycosuria in 2 patients. All 12 patients with abnormal urinalysis underwent further investigation in order to determine the cause of renal damage and the results are as follows: 2 patients had glomerulonephritis and in other 2 patients renal damage was due to medication adverse effect, 1 had pyelonephritis in combination with chronic active tubulointerstitial nephritis and another 1 had thin basement membrane disease. Three patients had IBD-related dependent renal involvement and 1 resulted in chronic renal failure due to amyloidosis.
CONCLUSIONS: It is important for all clinicians to be aware of the possibility of renal manifestations in IBD patients for the early diagnosis and prevention of these manifestations and complications.
摘要：
目的：肾脏受累于炎症性肠病是相当罕见的。这项研究旨在描述IBD儿科患者肾脏受累的频谱，并减少检测和管理的延迟。
方法：这是一项对所有患者肾功能的回顾性研究，年龄<18岁，从2019年1月到2023年1月，我们的儿科消化内科一直随访IBD。
结果：本研究纳入的75例IBD患者中，有16％有肾脏表现。尿液分析显示7例患者有蛋白尿，蛋白尿和血尿3例，蛋白尿和糖尿2例。对所有12例尿常规异常患者进行了进一步调查，以确定肾损害的原因，结果如下：2例患者患有肾小球肾炎，另外2例患者肾损害是由于药物不良反应。1例患有肾盂肾炎并伴有慢性活动性肾小管间质性肾炎，另1例患有薄基底膜疾病。3例患者患有IBD相关的依赖性肾脏受累，1例由于淀粉样变性而导致慢性肾功能衰竭。
结论：所有临床医生都必须意识到IBD患者肾脏表现的可能性，以便早期诊断和预防这些表现和并发症。
方法：这是一项对所有患者肾功能的回顾性研究，年龄<18岁，从2019年1月到2023年1月，我们的儿科消化内科一直随访IBD。
结果：本研究纳入的75例IBD患者中，有16％有肾脏表现。尿液分析显示7例患者有蛋白尿，蛋白尿和血尿3例，蛋白尿和糖尿2例。对所有12例尿常规异常患者进行了进一步调查，以确定肾损害的原因，结果如下：2例患者患有肾小球肾炎，另外2例患者肾损害是由于药物不良反应。1例患有肾盂肾炎并伴有慢性活动性肾小管间质性肾炎，另1例患有薄基底膜疾病。3例患者患有IBD相关的依赖性肾脏受累，1例由于淀粉样变性而导致慢性肾功能衰竭。
结论：所有临床医生都必须意识到IBD患者肾脏表现的可能性，以便早期诊断和预防这些表现和并发症。
