Abstract：
OBJECTIVE: To evaluate the histomorphometric and computerized microtomographic (Micro-CT) analysis of the regenerated bone tissue from maxillary sinus augmentation surgery, with and without using the collagen membrane on the external osteotomy window.
METHODS: Twelve patients were selected for this prospective, controlled, and randomized study. The patients were submitted to bilateral maxillary sinus surgery in a split-mouth design. On the test side, the maxillary sinus augmentation procedure included using Geistlich Bio-Oss® and a Geistlich Bio-Gide® collagen membrane covering the lateral osteotomy window. On the control side, only Geistlich Bio-Oss® was used without the presence of the membrane. After 6 months, the surgeries for implant installation were performed. In this surgical phase, specimens of the regenerated tissue were collected for histological and Micro-CT analysis.
RESULTS: In the histomorphometric evaluation, the mean (±SD) percentages of newly formed bone were 43.9% (±11.5) and 40.8% (±8.9) in the test and control groups, respectively. The corresponding values of the Micro-CT analysis were 36.6% (±3.4) and 37.2% (±4.7) in the test and control groups, respectively. There was no statistically significant difference between the test and control groups in the two methods. In addition, there was no statistically significant difference between the mean percentage of biomaterial remaining between the test and control groups. However, the mean percentage of newly formed bone was significantly higher and the mean percentage of remaining biomaterial was significantly lower in the histomorphometric analysis compared to the values obtained through microtomography.
CONCLUSIONS: The additional use of collagen membranes in maxillary sinus surgery does not offer advantages in newly formed bone.
METHODS: Twelve patients were selected for this prospective, controlled, and randomized study. The patients were submitted to bilateral maxillary sinus surgery in a split-mouth design. On the test side, the maxillary sinus augmentation procedure included using Geistlich Bio-Oss® and a Geistlich Bio-Gide® collagen membrane covering the lateral osteotomy window. On the control side, only Geistlich Bio-Oss® was used without the presence of the membrane. After 6 months, the surgeries for implant installation were performed. In this surgical phase, specimens of the regenerated tissue were collected for histological and Micro-CT analysis.
RESULTS: In the histomorphometric evaluation, the mean (±SD) percentages of newly formed bone were 43.9% (±11.5) and 40.8% (±8.9) in the test and control groups, respectively. The corresponding values of the Micro-CT analysis were 36.6% (±3.4) and 37.2% (±4.7) in the test and control groups, respectively. There was no statistically significant difference between the test and control groups in the two methods. In addition, there was no statistically significant difference between the mean percentage of biomaterial remaining between the test and control groups. However, the mean percentage of newly formed bone was significantly higher and the mean percentage of remaining biomaterial was significantly lower in the histomorphometric analysis compared to the values obtained through microtomography.
CONCLUSIONS: The additional use of collagen membranes in maxillary sinus surgery does not offer advantages in newly formed bone.
摘要：
目的：评估上颌窦强化手术再生骨组织的组织形态学和计算机显微CT（Micro-CT）分析，在外部截骨窗上使用和不使用胶原膜。
方法：选择12例患者进行前瞻性研究，控制,和随机研究。患者接受了裂口设计的双侧上颌窦手术。在测试方面，上颌窦增强手术包括使用GeistlichBio-Oss®和覆盖外侧截骨窗的GeistlichBio-Gide®胶原膜。在控制方面，仅使用GeistlichBio-Oss®而不存在膜。六个月后,进行了植入物安装的手术。在这个手术阶段，收集再生组织标本进行组织学和Micro-CT分析。
结果：在组织形态学评估中，试验组和对照组新生骨的平均百分比(±SD)分别为43.9%(±11.5)和40.8%(±8.9),分别。Micro-CT分析的相应值在试验组和对照组中分别为36.6%(±3.4)和37.2%(±4.7),分别。两种方法中试验组与对照组之间无统计学差异。此外,试验组和对照组之间剩余生物材料的平均百分比之间没有统计学上的显著差异.然而,与通过显微断层扫描获得的值相比,在组织形态计量学分析中,新形成的骨的平均百分比显著较高,剩余生物材料的平均百分比显著较低.
结论：在上颌窦手术中额外使用胶原膜并不能为新形成的骨提供优势。
方法：选择12例患者进行前瞻性研究，控制,和随机研究。患者接受了裂口设计的双侧上颌窦手术。在测试方面，上颌窦增强手术包括使用GeistlichBio-Oss®和覆盖外侧截骨窗的GeistlichBio-Gide®胶原膜。在控制方面，仅使用GeistlichBio-Oss®而不存在膜。六个月后,进行了植入物安装的手术。在这个手术阶段，收集再生组织标本进行组织学和Micro-CT分析。
结果：在组织形态学评估中，试验组和对照组新生骨的平均百分比(±SD)分别为43.9%(±11.5)和40.8%(±8.9),分别。Micro-CT分析的相应值在试验组和对照组中分别为36.6%(±3.4)和37.2%(±4.7),分别。两种方法中试验组与对照组之间无统计学差异。此外,试验组和对照组之间剩余生物材料的平均百分比之间没有统计学上的显著差异.然而,与通过显微断层扫描获得的值相比,在组织形态计量学分析中,新形成的骨的平均百分比显著较高,剩余生物材料的平均百分比显著较低.
结论：在上颌窦手术中额外使用胶原膜并不能为新形成的骨提供优势。
