Abstract：
UNASSIGNED: Cholera is a bacterial diarrheal disease caused by pathogen bacteria Vibrio cholerae, which produces the cholera toxin (CT). In addition to improving water sanitation, oral cholera vaccines have been developed to control infection. Besides, rehydration and antibiotic therapy are complementary treatment strategies for cholera. ToxT regulatory protein activates transcription of CT gene, which is enhanced by bicarbonate (HCO3-).
UNASSIGNED: This review delves into the genomic blueprint of V. cholerae, which encodes for α-, β-, and γ- carbonic anhydrases (CAs). We explore how the CAs contribute to the pathogenicity of V. cholerae and discuss the potential of CA inhibitors in mitigating the disease\'s impact.
UNASSIGNED: CA inhibitors can reduce the virulence of bacteria and control cholera. Here, we reviewed all reported CA inhibitors, noting that α-CA from V. cholerae (VchCAα) was the most effective inhibited enzyme compared to the β- and γ-CA families (VchCAβ and VchCAγ). Among the CA inhibitors, acyl selenobenzenesulfonamidenamides and simple/heteroaromatic sulfonamides were the best VchCA inhibitors in the nM range. It was noted that some antibacterial compounds show good inhibitory effects on all three bacterial CAs. CA inhibitors belonging to other classes may be synthesized and tested on VchCAs to harness cholera.
UNASSIGNED: This review delves into the genomic blueprint of V. cholerae, which encodes for α-, β-, and γ- carbonic anhydrases (CAs). We explore how the CAs contribute to the pathogenicity of V. cholerae and discuss the potential of CA inhibitors in mitigating the disease\'s impact.
UNASSIGNED: CA inhibitors can reduce the virulence of bacteria and control cholera. Here, we reviewed all reported CA inhibitors, noting that α-CA from V. cholerae (VchCAα) was the most effective inhibited enzyme compared to the β- and γ-CA families (VchCAβ and VchCAγ). Among the CA inhibitors, acyl selenobenzenesulfonamidenamides and simple/heteroaromatic sulfonamides were the best VchCA inhibitors in the nM range. It was noted that some antibacterial compounds show good inhibitory effects on all three bacterial CAs. CA inhibitors belonging to other classes may be synthesized and tested on VchCAs to harness cholera.
摘要：
霍乱是由致病菌霍乱弧菌引起的细菌性腹泻病,产生霍乱毒素（CT）。除了改善水卫生，已经开发了口服霍乱疫苗来控制感染。此外,补液和抗生素治疗是霍乱的补充治疗策略.ToxT调节蛋白激活CT基因转录,它是由碳酸氢盐（HCO3-）增强。
■这篇综述深入探讨了霍乱弧菌的基因组蓝图，编码α-，β-,和γ-碳酸酐酶(CAs)。我们探讨CA如何促进霍乱弧菌的致病性，并讨论CA抑制剂在减轻疾病影响方面的潜力。
■CA抑制剂可以降低细菌的毒力并控制霍乱。这里,我们回顾了所有报道的CA抑制剂，注意，与β-和γ-CA家族（VchCAβ和VchCAγ）相比，霍乱弧菌（VchCAα）的α-CA是最有效的抑制酶。在CA抑制剂中，酰基硒苯磺酰胺和简单/杂芳族磺酰胺是nM范围内最好的VchCA抑制剂。注意到一些抗菌化合物对所有三种细菌CA都显示出良好的抑制作用。可以合成属于其他类别的CA抑制剂，并在VchCA上进行测试以控制霍乱。
■这篇综述深入探讨了霍乱弧菌的基因组蓝图，编码α-，β-,和γ-碳酸酐酶(CAs)。我们探讨CA如何促进霍乱弧菌的致病性，并讨论CA抑制剂在减轻疾病影响方面的潜力。
■CA抑制剂可以降低细菌的毒力并控制霍乱。这里,我们回顾了所有报道的CA抑制剂，注意，与β-和γ-CA家族（VchCAβ和VchCAγ）相比，霍乱弧菌（VchCAα）的α-CA是最有效的抑制酶。在CA抑制剂中，酰基硒苯磺酰胺和简单/杂芳族磺酰胺是nM范围内最好的VchCA抑制剂。注意到一些抗菌化合物对所有三种细菌CA都显示出良好的抑制作用。可以合成属于其他类别的CA抑制剂，并在VchCA上进行测试以控制霍乱。
