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Abstract：
Hair cortisol concentration (HCC) and a questionnaire were used as indicators of chronic stress status and quality of life (QoL), respectively, in cats. To date, there has been limited research on the simultaneous application of both indicators in unwell cats. Our aim was to evaluate HCC and questionnaire data obtained from a healthy cat cohort (n = 61) and cat cohorts with either chronic kidney disease (CKD) (n = 78) or suspected feline infectious peritonitis (FIP) (n = 24). Furthermore, we also investigated the correlation between HCC and clinical pathological data. For this study, hair from the abdomen of cats was collected and analyzed for HCC using a commercial ELISA kit. Owners also completed a questionnaire, from which average-item-weighted-impact-scores (AWISs) were calculated. Cats with late-stage-CKD (median, HCC = 330.15 pg/mg, AWIS = -0.43) presented with a significantly higher HCC (p < 0.01) and a significantly lower AWIS (p < 0.01) than cats with early-stage-CKD (HCC = 183.56 pg/mg, AWIS = 1.08). Similarly, there were significant differences in both HCC (p < 0.001) and AWIS (p < 0.001) between cats with suspected FIP (HCC = 896.27 pg/mg, AWIS = -1.97) and healthy cats (HCC = 181.24 pg/mg, AWIS = 1.24). The degree of consistency between the HCC results and the questionnaire results reminds us that the severity of a chronic disease or the presence of a life-threatening disease can significantly increase stress and thus can affect the QoL of cats.
摘要：
头发皮质醇浓度（HCC）和问卷被用作慢性应激状态和生活质量（QoL）的指标，分别,在猫。迄今为止,关于两种指标在不适猫中同时应用的研究有限。我们的目的是评估从健康猫队列（n=61）和慢性肾病（CKD）（n=78）或疑似猫传染性腹膜炎（FIP）（n=24）的猫队列获得的HCC和问卷调查数据。此外，我们还调查了HCC与临床病理数据之间的相关性。对于这项研究，收集猫腹部的毛发并使用商业ELISA试剂盒分析HCC。业主还填写了一份问卷，从中计算平均项目加权影响评分(AWIS)。患有晚期CKD的猫(中位数，HCC=330.15pg/mg，AWIS=-0.43）与早期CKD（HCC=183.56pg/mg相比，HCC显着升高（p<0.01），AWIS显着降低（p<0.01），AWIS=1.08)。同样，怀疑FIP的猫之间的HCC（p<0.001）和AWIS（p<0.001）均存在显着差异（HCC=896.27pg/mg，AWIS=-1.97）和健康猫（HCC=181.24pg/mg，AWIS=1.24)。HCC结果和问卷结果之间的一致性程度提醒我们，慢性疾病的严重程度或危及生命的疾病的存在可以显着增加压力，因此可以影响猫的QoL。
