PDF(Pubmed)
Abstract：
BACKGROUND: Interventional valve implantation into the inferior vena cava (CAVI) lowers venous congestion in patients with tricuspid regurgitation (TR). We evaluated the impact of a reduction of abdominal venous congestion following CAVI on circulating immune cells and inflammatory mediators.
METHODS: Patients with severe TR were randomized to optimal medical therapy (OMT) + CAVI (n = 8) or OMT (n = 10). In the OMT + CAVI group, an Edwards Sapien XT valve was implanted into the inferior vena cava. Immune cells and inflammatory mediators were measured in the peripheral blood at baseline and three-month follow-up.
RESULTS: Leukocytes, monocytes, basophils, eosinophils, neutrophils, lymphocytes, B, T and natural killer cells and inflammatory markers (C-reactive protein, interferon-gamma, interleukin-2, -4, -5, -10, and tumor necrosis factor-alpha) did not change substantially between baseline and three-month follow-up within the OMT + CAVI and OMT group.
CONCLUSIONS: The present data suggest that reduction of venous congestion following OMT + CAVI may not lead to substantial changes in systemic inflammation within a short-term follow-up.
BACKGROUND: NCT02387697.
METHODS: Patients with severe TR were randomized to optimal medical therapy (OMT) + CAVI (n = 8) or OMT (n = 10). In the OMT + CAVI group, an Edwards Sapien XT valve was implanted into the inferior vena cava. Immune cells and inflammatory mediators were measured in the peripheral blood at baseline and three-month follow-up.
RESULTS: Leukocytes, monocytes, basophils, eosinophils, neutrophils, lymphocytes, B, T and natural killer cells and inflammatory markers (C-reactive protein, interferon-gamma, interleukin-2, -4, -5, -10, and tumor necrosis factor-alpha) did not change substantially between baseline and three-month follow-up within the OMT + CAVI and OMT group.
CONCLUSIONS: The present data suggest that reduction of venous congestion following OMT + CAVI may not lead to substantial changes in systemic inflammation within a short-term follow-up.
BACKGROUND: NCT02387697.
摘要：
背景：下腔静脉（CAVI）介入瓣膜植入可降低三尖瓣反流（TR）患者的静脉充血。我们评估了CAVI后腹部静脉充血减少对循环免疫细胞和炎症介质的影响。
方法：重度TR患者随机接受最佳药物治疗（OMT）+CAVI（n=8）或OMT（n=10）。在OMT+CAVI组中，将一个EdwardsSapienXT瓣膜植入下腔静脉。在基线和三个月随访时测量外周血中的免疫细胞和炎症介质。
结果：白细胞，单核细胞,嗜碱性粒细胞,嗜酸性粒细胞,中性粒细胞，淋巴细胞，B,T和自然杀伤细胞和炎症标志物（C反应蛋白，干扰素-γ，在OMT+CAVI和OMT组中,白细胞介素-2,-4,-5,-10和肿瘤坏死因子-α)在基线和3个月随访之间没有实质性变化.
结论：目前的数据表明，OMT+CAVI后静脉充血的减少可能不会导致短期随访中全身性炎症的实质性变化。
背景：NCT02387697。
方法：重度TR患者随机接受最佳药物治疗（OMT）+CAVI（n=8）或OMT（n=10）。在OMT+CAVI组中，将一个EdwardsSapienXT瓣膜植入下腔静脉。在基线和三个月随访时测量外周血中的免疫细胞和炎症介质。
结果：白细胞，单核细胞,嗜碱性粒细胞,嗜酸性粒细胞,中性粒细胞，淋巴细胞，B,T和自然杀伤细胞和炎症标志物（C反应蛋白，干扰素-γ，在OMT+CAVI和OMT组中,白细胞介素-2,-4,-5,-10和肿瘤坏死因子-α)在基线和3个月随访之间没有实质性变化.
结论：目前的数据表明，OMT+CAVI后静脉充血的减少可能不会导致短期随访中全身性炎症的实质性变化。
背景：NCT02387697。
