Abstract：
mGlu2/3 Receptors (LY354740) in Anxiety mGlu2/3 receptors when activated decrease glutamate excitation on limbic synapses involved in anxiety. The orally active agonist compound LY354740 (or prodrug LY544344) was active in animal and human models of stress/anxiety. Later clinical studies showed efficacy in generalized anxiety in patients, validating this mechanism clinically. However, the compound was terminated due to rodent seizures in long-term toxicology studies.
摘要：
焦虑mGlu2/3受体中的mGlu2/3受体（LY354740）在激活时降低与焦虑有关的边缘突触的谷氨酸激发。口服活性激动剂化合物LY354740(或前药LY544344)在应激/焦虑的动物和人类模型中具有活性。后来的临床研究表明，患者广泛性焦虑的疗效，在临床上验证这种机制。然而,在长期毒理学研究中,该化合物因啮齿动物癫痫发作而终止.
