%0 Journal Article
%T mGlu2/3 receptor agonist (LY354740) in anxiety.
%A Schoepp DD
%J Pharmacol Biochem Behav
%V 242
%N 0
%D 2024 Sep 18
%M 39025335
%F 3.697
%R 10.1016/j.pbb.2024.173826
%X mGlu2/3 Receptors (LY354740) in Anxiety mGlu2/3 receptors when activated decrease glutamate excitation on limbic synapses involved in anxiety. The orally active agonist compound LY354740 (or prodrug LY544344) was active in animal and human models of stress/anxiety. Later clinical studies showed efficacy in generalized anxiety in patients, validating this mechanism clinically. However, the compound was terminated due to rodent seizures in long-term toxicology studies.