{Reference Type}: Journal Article
{Title}: mGlu2/3 receptor agonist (LY354740) in anxiety.
{Author}: Schoepp DD;
{Journal}: Pharmacol Biochem Behav
{Volume}: 242
{Issue}: 0
{Year}: 2024 Sep 18
{Factor}: 3.697
{DOI}: 10.1016/j.pbb.2024.173826
{Abstract}: mGlu2/3 Receptors (LY354740) in Anxiety mGlu2/3 receptors when activated decrease glutamate excitation on limbic synapses involved in anxiety. The orally active agonist compound LY354740 (or prodrug LY544344) was active in animal and human models of stress/anxiety. Later clinical studies showed efficacy in generalized anxiety in patients, validating this mechanism clinically. However, the compound was terminated due to rodent seizures in long-term toxicology studies.