Abstract：
The study objective is to examine epidemiological and microbiological aspects of aerobic vaginitis in female patients admitted to University Hospital of Campania \"L. Vanvitelli\" over five years. The most represented strains were E. coli (n = 153), Citrobacter spp. increasing from 2020, E. faecalis (n = 149), S. haemolitycus (n = 61), and Candida albicans (n = 87). The susceptibility patterns of a selection of gram-negative and gram-positive representative bacterial isolates were examined. Carbapenems, aminoglycosides, and fosfomycin were most effective against gram-negative bacteria, whereas vancomycin, daptomycin, and linezolid exhibited greater efficacy against gram-positive bacteria. None of the E. coli and Citrobacter spp. isolates produced extended-spectrum beta-lactamases, and the S. haemolyticus strains were methicillin-resistant. In gram-positive isolates, gentamicin susceptibility increased in 2020 and 2021 compared to clindamycin; erythromycin showed high resistance rates in 2020. Our findings indicate that integrating proper microbiological cultures into clinical practice could improve the management of aerobic vaginitis. Moreover, they highlight the necessity of establishing a nationwide surveillance guideline to mitigate antimicrobial resistance. Improvement actions in antimicrobial diagnostic stewardship must be considered when seeking the appropriate diagnosis and treatment for aerobic vaginitis.
摘要：
研究目的是检查坎帕尼亚大学医院收治的女性患者需氧性阴道炎的流行病学和微生物学方面。Vanvitelli“超过五年。代表最多的菌株是大肠杆菌(n=153)，柠檬酸杆菌属。从2020年开始，粪肠球菌(n=149)，S、血球（n=61），和白色念珠菌（n=87）。检查了革兰氏阴性和革兰氏阳性代表性细菌分离株的敏感性模式。碳青霉烯类,氨基糖苷类,磷霉素对革兰氏阴性菌最有效，而万古霉素，达托霉素,利奈唑胺对革兰氏阳性菌表现出更大的疗效。没有大肠杆菌和柠檬酸杆菌属。分离株产生广谱β-内酰胺酶，溶血链球菌菌株耐甲氧西林。在革兰氏阳性分离株中，与克林霉素相比，庆大霉素的敏感性在2020年和2021年增加；红霉素在2020年表现出很高的耐药率。我们的发现表明，将适当的微生物培养物纳入临床实践可以改善需氧性阴道炎的管理。此外，他们强调了建立全国性监测指南以减轻抗菌素耐药性的必要性.在寻求好氧性阴道炎的适当诊断和治疗时，必须考虑在抗菌诊断管理方面的改进措施。
