PDF(Pubmed)
Abstract：
UNASSIGNED: People living with HIV (PLWH) experience high rates of childhood trauma exposure, which is a significant risk factor for the development of posttraumatic stress disorder (PTSD). Because Black Americans living in urban environments are exposed to high levels of trauma, suffer from chronic PTSD, and are at increased risk for HIV infection, it is important to understand how HIV status interacts with childhood maltreatment to influence PTSD symptom severity and underlying psychophysiology.
UNASSIGNED: The current cross-sectional study assessed whether HIV status interacts with childhood maltreatment to influence PTSD symptom severity and heart rate variability during a dark-enhanced startle (DES) task in 88 Black women with (n=30) and without HIV (n=58).
UNASSIGNED: HIV was associated with greater PTSD symptom severity only in women with low levels of childhood maltreatment (p=.024). Startle potentiation during DES was highest in women living without HIV and with high childhood maltreatment (p=.018). In women who had experienced low levels of childhood maltreatment, respiratory sinus arrhythmia (RSA) was lower during the dark phase of DES in women living without HIV than women living with HIV (WLWH), (p=.046). RSA during the light phase of DES was lower in WLWH than in women living without HIV (p=.042).
UNASSIGNED: In the current sample of Black women, HIV status was associated with PTSD symptom severity in a manner dependent on level of childhood maltreatment, suggesting that HIV status may be an important factor to consider for behavioral and pharmacological treatment strategies for PTSD. Additionally, HIV status is associated with lower percent potentiation to darkness and lower RSA during the light phase of DES, suggesting physiological mechanisms by which HIV may contribute to PTSD symptoms in individuals exposed to low levels of childhood maltreatment.
UNASSIGNED: The current cross-sectional study assessed whether HIV status interacts with childhood maltreatment to influence PTSD symptom severity and heart rate variability during a dark-enhanced startle (DES) task in 88 Black women with (n=30) and without HIV (n=58).
UNASSIGNED: HIV was associated with greater PTSD symptom severity only in women with low levels of childhood maltreatment (p=.024). Startle potentiation during DES was highest in women living without HIV and with high childhood maltreatment (p=.018). In women who had experienced low levels of childhood maltreatment, respiratory sinus arrhythmia (RSA) was lower during the dark phase of DES in women living without HIV than women living with HIV (WLWH), (p=.046). RSA during the light phase of DES was lower in WLWH than in women living without HIV (p=.042).
UNASSIGNED: In the current sample of Black women, HIV status was associated with PTSD symptom severity in a manner dependent on level of childhood maltreatment, suggesting that HIV status may be an important factor to consider for behavioral and pharmacological treatment strategies for PTSD. Additionally, HIV status is associated with lower percent potentiation to darkness and lower RSA during the light phase of DES, suggesting physiological mechanisms by which HIV may contribute to PTSD symptoms in individuals exposed to low levels of childhood maltreatment.
摘要：
■艾滋病毒携带者（PLWH）儿童创伤暴露率高，这是创伤后应激障碍（PTSD）发展的重要危险因素。因为生活在城市环境中的美国黑人面临着严重的创伤，患有慢性创伤后应激障碍，并且感染艾滋病毒的风险增加，重要的是要了解艾滋病毒状况如何与儿童虐待相互作用,从而影响PTSD症状的严重程度和潜在的心理生理学.
■当前的横断面研究评估了在88名有（n=30）和没有HIV（n=58）的黑人女性中，在黑暗增强的惊吓（DES）任务中，HIV状况是否与儿童虐待相互作用，以影响PTSD症状的严重程度和心率变异性。
■HIV仅在儿童虐待程度较低的女性中与PTSD症状严重程度相关（p=.024）。DES期间的惊吓增强在没有艾滋病毒和儿童虐待的女性中最高（p=.018）。在经历过低水平童年虐待的女性中，在DES的黑暗阶段，没有艾滋病毒的女性的呼吸窦性心律失常（RSA）低于感染艾滋病毒的女性（WLWH），（p=0.046）。WLWH在DES轻度阶段的RSA低于没有HIV的女性（p=.042）。
■在当前的黑人女性样本中，HIV状态与创伤后应激障碍症状严重程度相关，取决于儿童虐待的程度，提示HIV状态可能是PTSD的行为和药物治疗策略需要考虑的重要因素。此外,在DES的光照阶段，HIV状态与较低的黑暗增强百分比和较低的RSA有关，提示在暴露于低水平儿童虐待的个体中，HIV可能导致PTSD症状的生理机制。
■当前的横断面研究评估了在88名有（n=30）和没有HIV（n=58）的黑人女性中，在黑暗增强的惊吓（DES）任务中，HIV状况是否与儿童虐待相互作用，以影响PTSD症状的严重程度和心率变异性。
■HIV仅在儿童虐待程度较低的女性中与PTSD症状严重程度相关（p=.024）。DES期间的惊吓增强在没有艾滋病毒和儿童虐待的女性中最高（p=.018）。在经历过低水平童年虐待的女性中，在DES的黑暗阶段，没有艾滋病毒的女性的呼吸窦性心律失常（RSA）低于感染艾滋病毒的女性（WLWH），（p=0.046）。WLWH在DES轻度阶段的RSA低于没有HIV的女性（p=.042）。
■在当前的黑人女性样本中，HIV状态与创伤后应激障碍症状严重程度相关，取决于儿童虐待的程度，提示HIV状态可能是PTSD的行为和药物治疗策略需要考虑的重要因素。此外,在DES的光照阶段，HIV状态与较低的黑暗增强百分比和较低的RSA有关，提示在暴露于低水平儿童虐待的个体中，HIV可能导致PTSD症状的生理机制。
