Abstract：
BACKGROUND: Approximately 16.5% of U.S. young adults have a cannabis use disorder (CUD) and are at risk for negative outcomes. Treatment can reduce cannabis use, but young adults are less likely to seek help than older adults. Peer Network Counseling-txt (PNC-txt) is a brief, text-delivered, Motivational Interviewing-informed substance use intervention focusing on peer relations and activity spaces as mechanisms for behavioral change. PNC-txt has shown evidence of reducing tobacco and cannabis use with adolescents and young adults, but it has not been tested in the context of legal cannabis use. The current randomized controlled trial sought to expand the evidence regarding the context of PNC-txt effects, comparing one state in which cannabis is legal (Colorado) and one state in which it is not (Tennessee). We hypothesized that participants randomized to PNC-txt would show significant reductions in cannabis use compared to controls, with larger reductions for females and those in Colorado, and that peer relations and activity space would mediate effects.
METHODS: One thousand, seventy eight 18-25 year olds (CO: 551; TN: 527) who met screening criteria for CUD and biologically-verified cannabis use were randomly assigned to PNC-txt or waitlist control condition. Every other day for 4 weeks, participants assigned to PNC-txt received pre-programmed text conversations, tailored via data from the baseline assessment. Self-report and biological indicators of cannabis use were measured at 1-, 3-, and 6-months.
CONCLUSIONS: Data analysis is underway. Results will provide evidence regarding whether, and how, PNC-txt reduces cannabis use in young adults with CUD.
BACKGROUND: This trial was prospectively registered on September 28, 2020 with ClinicalTrials.gov (NCT04567394).
METHODS: One thousand, seventy eight 18-25 year olds (CO: 551; TN: 527) who met screening criteria for CUD and biologically-verified cannabis use were randomly assigned to PNC-txt or waitlist control condition. Every other day for 4 weeks, participants assigned to PNC-txt received pre-programmed text conversations, tailored via data from the baseline assessment. Self-report and biological indicators of cannabis use were measured at 1-, 3-, and 6-months.
CONCLUSIONS: Data analysis is underway. Results will provide evidence regarding whether, and how, PNC-txt reduces cannabis use in young adults with CUD.
BACKGROUND: This trial was prospectively registered on September 28, 2020 with ClinicalTrials.gov (NCT04567394).
摘要：
背景：大约16.5％的美国年轻人患有大麻使用障碍（CUD），并且有负面结果的风险。治疗可以减少大麻的使用，但是年轻人比老年人更不可能寻求帮助。对等网络咨询-txt(PNC-txt)是一个简短的，文本交付，动机性访谈知情物质使用干预措施，重点关注同伴关系和活动空间作为行为改变的机制。PNC-txt已显示出减少青少年和年轻人使用烟草和大麻的证据，但尚未在合法使用大麻的情况下进行测试。目前的随机对照试验试图扩大关于PNC-txt效应背景的证据，比较大麻合法的州（科罗拉多州）和不合法的州（田纳西州）。我们假设随机分配到PNC-txt的参与者与对照组相比，大麻的使用显着减少，女性和科罗拉多州的女性减少幅度更大，同伴关系和活动空间将调解效果。
方法：一千个，符合CUD筛查标准和经生物验证的大麻使用情况的78名18-25岁(CO:551;TN:527)被随机分配至PNC-txt或等待名单控制条件.每隔一天，连续4周，分配给PNC-txt的参与者收到了预编程的文本对话，通过基线评估的数据定制。大麻使用的自我报告和生物学指标在1-，3-,和6个月。
结论：数据分析正在进行中。结果将提供有关是否，以及如何，PNC-txt减少了CUD年轻人的大麻使用。
背景：该试验于2020年9月28日在ClinicalTrials.gov（NCT04567394）进行了前瞻性注册。
方法：一千个，符合CUD筛查标准和经生物验证的大麻使用情况的78名18-25岁(CO:551;TN:527)被随机分配至PNC-txt或等待名单控制条件.每隔一天，连续4周，分配给PNC-txt的参与者收到了预编程的文本对话，通过基线评估的数据定制。大麻使用的自我报告和生物学指标在1-，3-,和6个月。
结论：数据分析正在进行中。结果将提供有关是否，以及如何，PNC-txt减少了CUD年轻人的大麻使用。
背景：该试验于2020年9月28日在ClinicalTrials.gov（NCT04567394）进行了前瞻性注册。
