PDF(Pubmed)
Abstract：
Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca2+ concentration ([Ca2+]i), brought on by persistent metabolic stimulation of β-cells, causes β-cell dysfunction and failure by adversely affecting β-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca2+]i impairs β-cell function.
摘要：
早期的2型糖尿病（T2D）的发展，胰岛素抵抗和营养超负荷引起的代谢应激引起β细胞过度刺激。在这里，我们总结了最近的研究，探索了细胞内Ca2+浓度增加的前提（[Ca2+]i），由β细胞持续的代谢刺激引起，通过对β细胞功能产生不利影响而导致β细胞功能障碍和衰竭，结构,和身份。这篇小型评论建立在最近的几篇评论的基础上，这些评论还描述了过量的[Ca2]i如何损害β细胞功能。
