%0 Journal Article
%T Ca2+ signaling and metabolic stress-induced pancreatic β-cell failure.
%A Magnuson MA
%A Osipovich AB
%J Front Endocrinol (Lausanne)
%V 15
%N 0
%D 2024
%M 39015185
%F 6.055
%R 10.3389/fendo.2024.1412411
%X Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca2+ concentration ([Ca2+]i), brought on by persistent metabolic stimulation of β-cells, causes β-cell dysfunction and failure by adversely affecting β-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca2+]i impairs β-cell function.