Abstract：
Emotional intelligence (EI) and neurocognition (NC) impairments are common in first-episode psychosis (FEP), yet their evolution over time remains unclear. This study identified patient profiles in EI and NC performance in FEP. 98 adult FEP patients and 128 healthy controls (HCs) were tested on clinical, functional, EI, and NC variables at baseline and two-year follow-up (FUP). A repeated-measures ANOVA compared the effects of group (patients and HCs) and time on EI. Significant EI improvements were observed in both groups. Four groups were created based on NC and EI performance at baseline and FUP in patients: impairment in NC and EI, impairment in NC only, impairment in EI only, and no impairment. At FUP, patients impaired in NC and EI showed less cognitive reserve (CR), greater negative and positive symptoms, and poorer functional outcomes. At FUP, three group trajectories were identified: (I) maintain dual impairment (II) maintain no impairment or improve, (III) maintain sole impairment or worsen. The maintain dual impairment group had the lowest levels of CR. EI and NC impairments progress differently in FEP. Greater CR may protect against comorbid EI/NC impairment. Identifying these patient characteristics could contribute to the development of personalised interventions.
摘要：
情绪智力（EI）和神经认知（NC）障碍在首发精神病（FEP）中很常见，然而，随着时间的推移，它们的演变仍不清楚。这项研究确定了EI中的患者概况和FEP中的NC表现。98名成人FEP患者和128名健康对照（HC）进行了临床测试，功能，EI,基线和两年随访(FUP)时的NC变量。重复测量方差分析比较了组（患者和HCs）和时间对EI的影响。在两组中均观察到显着的EI改善。根据患者基线和FUP的NC和EI表现创建四组：NC和EI受损，仅在NC中受损，仅在EI中受损，也没有损害。在FUP,NC和EI受损的患者表现出更低的认知储备（CR），更大的阴性和阳性症状，和较差的功能结果。在FUP,确定了三组轨迹：（I）维持双重损害（II）维持无损害或改善，(三)保持单一减值或恶化。维持双重损伤组的CR水平最低。EI和NC损伤在FEP中的进展不同。更大的CR可以防止并发EI/NC损害。识别这些患者特征可能有助于开发个性化干预措施。
