Abstract：
BACKGROUND: This study explored the efficacy of repeat blood cultures in bacteremic acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HSCT).
METHODS: This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacteremia following HSCT at the Taussig Cancer Center from January 1, 2019, to December 31, 2022. The primary endpoint was the rate of positive repeat blood cultures following initial positive blood culture.
RESULTS: Fifty patients were included in the study. There were 50 occurrences of FN with positive initial blood cultures that were diagnosed following HSCT. Fifty initial sets of blood cultures and 96 sets of repeat blood cultures were drawn between the 50 occurrences of FN. Twelve of 96 (12.5%) repeat blood culture sets were positive for a pathogen, which occurred over nine of 50 (18.0%) episodes of FN. Three of 96 (3.2%) repeat blood culture sets grew a pathogen that differed from the pathogen that grew in the preceding positive blood culture.
CONCLUSIONS: Among bacteremic AML patients in the post-HSCT period, the yield of repeat blood cultures for detecting previously detected and new pathogens was low.
METHODS: This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacteremia following HSCT at the Taussig Cancer Center from January 1, 2019, to December 31, 2022. The primary endpoint was the rate of positive repeat blood cultures following initial positive blood culture.
RESULTS: Fifty patients were included in the study. There were 50 occurrences of FN with positive initial blood cultures that were diagnosed following HSCT. Fifty initial sets of blood cultures and 96 sets of repeat blood cultures were drawn between the 50 occurrences of FN. Twelve of 96 (12.5%) repeat blood culture sets were positive for a pathogen, which occurred over nine of 50 (18.0%) episodes of FN. Three of 96 (3.2%) repeat blood culture sets grew a pathogen that differed from the pathogen that grew in the preceding positive blood culture.
CONCLUSIONS: Among bacteremic AML patients in the post-HSCT period, the yield of repeat blood cultures for detecting previously detected and new pathogens was low.
摘要：
背景：本研究探讨了在异基因造血干细胞移植（HSCT）后的急性髓性白血病（AML）患者中重复血培养的疗效。
方法：这是一项对2019年1月1日至2022年12月31日在Taussig癌症中心进行HSCT后出现发热性中性粒细胞减少症（FN）和菌血症的AML患者的回顾性研究。主要终点是初始阳性血液培养后的阳性重复血液培养率。
结果：50名患者被纳入研究。在HSCT后诊断出50例FN的初始血液培养阳性。在FN的50次发生之间，抽取了50组初始血液培养物和96组重复血液培养物。96个（12.5％）重复血液培养组中的12个对病原体呈阳性，发生在50次FN发作中的9次(18.0%)。96个重复血液培养组中的三个（3.2％）产生的病原体与先前阳性血液培养物中生长的病原体不同。
结论：在HSCT后的细菌性AML患者中，用于检测先前检测到的和新病原体的重复血液培养的产量很低。
方法：这是一项对2019年1月1日至2022年12月31日在Taussig癌症中心进行HSCT后出现发热性中性粒细胞减少症（FN）和菌血症的AML患者的回顾性研究。主要终点是初始阳性血液培养后的阳性重复血液培养率。
结果：50名患者被纳入研究。在HSCT后诊断出50例FN的初始血液培养阳性。在FN的50次发生之间，抽取了50组初始血液培养物和96组重复血液培养物。96个（12.5％）重复血液培养组中的12个对病原体呈阳性，发生在50次FN发作中的9次(18.0%)。96个重复血液培养组中的三个（3.2％）产生的病原体与先前阳性血液培养物中生长的病原体不同。
结论：在HSCT后的细菌性AML患者中，用于检测先前检测到的和新病原体的重复血液培养的产量很低。
