Abstract：
The present study analyses the clinical characteristics of patients diagnosed with cutaneous fusarium through a systematic review of cases reported in literature. A total of 39 cases were included, of which 53% were men, 30% were women, and in 17% the sex was not specified. The age ranged from 5 to 85 years. Most cases were reported in Brazil, followed by Japan and United States of America. The most common agent was Fusarium solani, in 37.5% of the patients. Most of the affected individuals had acute myeloid leukaemia and some of the predisposing factors, which included induction chemotherapy, febrile neutropenia, and bone marrow transplantation. The clinical topography of the lesions was located in 27.5% and disseminated in 72.5%, with the most observed clinical feature outstanding the presence of papules and nodules with central necrosis in 47% of the cases. Longer survival was demonstrated in those treated with more than three antifungals. It is concluded that cutaneous fusarium is a complex and challenging clinical entity, infection in patients with leukaemias underscores the need for thorough care to decrease morbidity and mortality.
摘要：
本研究通过对文献报道的病例进行系统回顾，分析了诊断为皮肤镰刀菌的患者的临床特征。共纳入39例，其中53%是男性，30%是女性,17%的人没有具体说明性别。年龄5~85岁。大多数病例是在巴西报告的，其次是日本和美利坚合众国。最常见的病原体是镰刀菌，37.5%的患者。大多数受影响的个体患有急性髓系白血病和一些诱发因素，其中包括诱导化疗，发热性中性粒细胞减少症,和骨髓移植。病灶的临床形态占27.5%，播散占72.5%，最明显的临床特征是47％的病例中出现丘疹和结节并伴有中央坏死。在用三种以上的抗真菌药物治疗的患者中证明了更长的存活率。结论皮肤镰刀菌是一个复杂而具有挑战性的临床实体，白血病患者的感染强调需要进行彻底的护理以降低发病率和死亡率.
