Abstract：
Schistosomiasis is a major cause of morbidity in the world and almost 800 million people worldwide are at risk for schistosomiasis; it is second only to malaria as a major infectious disease. Globally, it is estimated that the disease affects more than 250 million people in 78 countries of the world and is responsible for some 280,000-500,000 deaths each year. The three major schistosomes infecting humans are Schistosoma mansoni, S. japonicum, and S. haematobium. This chapter covers a wide range of aspects of schistosomiasis, including basic biology of the parasites, epidemiology, immunopathology, treatment, control, vaccines, and genomics/proteomics. In this chapter, the reader will understand the significant toll this disease takes in terms of mortality and morbidity. A description of the various life stages of schistosomes is presented, which will be informative for both those unfamiliar with the disease and experienced scientists. Clinical and public health aspects are addressed that cover acute and chronic disease, diagnosis, current treatment regimens and alternative drugs, and schistosomiasis control programs. A brief overview of genomics and proteomics is included that details recent advances in the field that will help scientists investigate the molecular biology of schistosomes. The reader will take away an appreciation for general aspects of schistosomiasis and the current research advances.
摘要：
血吸虫病是世界上发病率的主要原因，全世界有近8亿人面临血吸虫病的风险；它是仅次于疟疾的主要传染病。全球范围内,据估计，该病影响了世界78个国家的2.5亿多人，每年约有28万至50万人死亡。感染人类的三大血吸虫是曼氏血吸虫,日本血吸虫，和S.Hematomium。本章涵盖了血吸虫病的广泛方面，包括寄生虫的基本生物学，流行病学,免疫病理学，治疗,control,疫苗,和基因组学/蛋白质组学。在这一章中,读者将了解这种疾病在死亡率和发病率方面的重大损失。介绍了血吸虫的各个生命阶段的描述，这将为那些不熟悉这种疾病和有经验的科学家提供信息。涉及急性和慢性疾病的临床和公共卫生方面，诊断,目前的治疗方案和替代药物，和血吸虫病控制计划。包括基因组学和蛋白质组学的简要概述，详细介绍了该领域的最新进展，这将有助于科学家研究血吸虫的分子生物学。读者将对血吸虫病的一般方面和当前的研究进展表示赞赏。
