6 - 苯胺基咪唑并 [4, 5 - c] 吡啶 - 2 - 酮作为选择性 DNA 依赖性蛋白激酶抑制剂的鉴定及其作为放射增敏剂的应用。
Mesh : Humans DNA-Activated Protein Kinase / antagonists & inhibitors metabolism Animals Protein Kinase Inhibitors / pharmacology chemistry pharmacokinetics chemical synthesis Radiation-Sensitizing Agents / pharmacology chemistry pharmacokinetics chemical synthesis Structure-Activity Relationship Mice Cell Line, Tumor Imidazoles / pharmacology chemistry chemical synthesis pharmacokinetics Pyridones / pharmacology chemistry chemical synthesis pharmacokinetics Xenograft Model Antitumor Assays Mice, Nude Rats
来 源:
DOI:10.1021/acs.jmedchem.4c01120
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