Abstract：
UNASSIGNED: Ethylene glycol poisoning causes metabolic acidosis, organ injury, and death. Ethylene glycol testing is unavailable in many areas. Our laboratory uses an automated glycerol dehydrogenase enzymatic assay to screen for ethylene glycol. We sought to determine how often ethylene glycol results were available within 12 h of the first dose of fomepizole.
UNASSIGNED: Records from a single poison center were reviewed from December 2016 to December 2019. Cases were identified by searching for cases that received fomepizole. Outcomes included whether results were available within 12 h, and the turnaround time from time of laboratory order to result.
UNASSIGNED: Of the 125 cases of suspected toxic alcohol poisoning identified, 73 had screening for ethylene glycol by enzymatic assay. Results were available within 12 h of the initial fomepizole dose in 58 (79%) cases with a median turnaround time of 391 min.
UNASSIGNED: We have demonstrated clinically acceptable turnaround times using an automated screening ethylene glycol assay. The major limitations include lack of approval for this test at this time, the use of voluntarily reported poison center data, and lack of assessment of patient outcomes.
UNASSIGNED: Enzymatic screening for ethylene glycol yielded results within 12 h in 79% of cases.
UNASSIGNED: Records from a single poison center were reviewed from December 2016 to December 2019. Cases were identified by searching for cases that received fomepizole. Outcomes included whether results were available within 12 h, and the turnaround time from time of laboratory order to result.
UNASSIGNED: Of the 125 cases of suspected toxic alcohol poisoning identified, 73 had screening for ethylene glycol by enzymatic assay. Results were available within 12 h of the initial fomepizole dose in 58 (79%) cases with a median turnaround time of 391 min.
UNASSIGNED: We have demonstrated clinically acceptable turnaround times using an automated screening ethylene glycol assay. The major limitations include lack of approval for this test at this time, the use of voluntarily reported poison center data, and lack of assessment of patient outcomes.
UNASSIGNED: Enzymatic screening for ethylene glycol yielded results within 12 h in 79% of cases.
摘要：
■乙二醇中毒引起代谢性酸中毒，器官损伤,和死亡。乙二醇测试在许多领域是不可用的。我们的实验室使用自动甘油脱氢酶酶测定法来筛选乙二醇。我们试图确定在第一剂福美哌唑的12小时内获得乙二醇结果的频率。
■从2016年12月至2019年12月审查了单个毒物中心的记录。通过搜索接受福美哌唑的病例来确定病例。结果包括结果是否在12小时内可用，以及从实验室订单到结果的周转时间。
■在确定的125例疑似有毒酒精中毒病例中，73通过酶促测定筛选乙二醇。结果在58例（79％）患者的初始fomepizole剂量后12小时内可用，中位周转时间为391分钟。
■我们已经使用自动筛选乙二醇测定法证明了临床上可接受的周转时间。主要限制包括目前缺乏对该测试的批准，使用自愿报告的毒物中心数据，缺乏对患者预后的评估。
■在79%的病例中,对乙二醇的酶筛选在12小时内产生结果。
■从2016年12月至2019年12月审查了单个毒物中心的记录。通过搜索接受福美哌唑的病例来确定病例。结果包括结果是否在12小时内可用，以及从实验室订单到结果的周转时间。
■在确定的125例疑似有毒酒精中毒病例中，73通过酶促测定筛选乙二醇。结果在58例（79％）患者的初始fomepizole剂量后12小时内可用，中位周转时间为391分钟。
■我们已经使用自动筛选乙二醇测定法证明了临床上可接受的周转时间。主要限制包括目前缺乏对该测试的批准，使用自愿报告的毒物中心数据，缺乏对患者预后的评估。
■在79%的病例中,对乙二醇的酶筛选在12小时内产生结果。
