Abstract：
OBJECTIVE: The objective of this research was to explore the associations between dietary PUFAs intake and hyperuricemia risk.
RESULTS: Based on the National Health and Nutrition Examination Survey (NHANES) 2003-2015, all eligible individuals were divided into hyperuricemia and non-hyperuricemia groups based on diagnostic criteria for hyperuricemia (serum uric acid >420 μmol/L for men and >360 μmol/L for women). Multivariate-adjusted logistic regression was employed to explore the relationship between dietary PUFAs intake and hyperuricemia risk. Total PUFAs and their subtypes were modeled to isocalorically replace saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). Higher intake of n-3 PUFAs, n-6 PUFAs, linoleic acid (LA), alpha-linoleic acid (ALA), and non-marine PUFAs intake correlated with decreased hyperuricemia risk, with adjusted odds ratio (OR) and 95% confidence interval (95%CIs) were 0.77 (0.63, 0.93), 0.75 (0.61, 0.92), 0.75 (0.61, 0.91), 0.69 (0.55, 0.87), and 0.73 (0.59, 0.91), respectively. Replacing 5% of total energy intake from SFAs with isocaloric PUFAs was associated with decreased odds of hyperuricemia in men (0.69 (0.57, 0.84)) and in individuals (0.81 (0.71, 0.92)). Similar trends were observed in the substitution of SFAs with non-marine PUFAs in men (0.87 (0.80, 0.94)) and in all individuals (0.92 (0.88, 0.98)). Sensitivity analyses exhibited consistent results with primary analyses.
CONCLUSIONS: Higher dietary intake of n-3 PUFAs, n-6 PUFAs, LA, ALA, and non-marine PUFAs was associated with decreased hyperuricemia risk. These results support the recommendation to substitute SFAs with PUFAs in diet.
RESULTS: Based on the National Health and Nutrition Examination Survey (NHANES) 2003-2015, all eligible individuals were divided into hyperuricemia and non-hyperuricemia groups based on diagnostic criteria for hyperuricemia (serum uric acid >420 μmol/L for men and >360 μmol/L for women). Multivariate-adjusted logistic regression was employed to explore the relationship between dietary PUFAs intake and hyperuricemia risk. Total PUFAs and their subtypes were modeled to isocalorically replace saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). Higher intake of n-3 PUFAs, n-6 PUFAs, linoleic acid (LA), alpha-linoleic acid (ALA), and non-marine PUFAs intake correlated with decreased hyperuricemia risk, with adjusted odds ratio (OR) and 95% confidence interval (95%CIs) were 0.77 (0.63, 0.93), 0.75 (0.61, 0.92), 0.75 (0.61, 0.91), 0.69 (0.55, 0.87), and 0.73 (0.59, 0.91), respectively. Replacing 5% of total energy intake from SFAs with isocaloric PUFAs was associated with decreased odds of hyperuricemia in men (0.69 (0.57, 0.84)) and in individuals (0.81 (0.71, 0.92)). Similar trends were observed in the substitution of SFAs with non-marine PUFAs in men (0.87 (0.80, 0.94)) and in all individuals (0.92 (0.88, 0.98)). Sensitivity analyses exhibited consistent results with primary analyses.
CONCLUSIONS: Higher dietary intake of n-3 PUFAs, n-6 PUFAs, LA, ALA, and non-marine PUFAs was associated with decreased hyperuricemia risk. These results support the recommendation to substitute SFAs with PUFAs in diet.
摘要：
目的：本研究的目的是探讨膳食PUFA摄入量与高尿酸血症风险之间的关系。
结果：根据2003-2015年全国健康与营养调查（NHANES），根据高尿酸血症诊断标准（男性血尿酸>420μmol/L，女性血尿酸>360μmol/L）将所有符合条件的个体分为高尿酸血症组和非高尿酸血症组。采用多因素调整逻辑回归分析膳食PUFA摄入量与高尿酸血症风险之间的关系。对总PUFA及其亚型进行建模，以等热地替代饱和脂肪酸（SFA）和单不饱和脂肪酸（MUFA）。较高的n-3PUFA摄入量，n-6PUFA,亚油酸（LA），α-亚油酸（ALA），非海洋PUFA摄入量与高尿酸血症风险降低相关，调整后的比值比(OR)和95%置信区间(95CIs)为0.77(0.63，0.93)，0.75（0.61，0.92），0.75（0.61，0.91），0.69（0.55，0.87），和0.73（0.59，0.91），分别。在男性(0.69(0.57,0.84))和个体(0.81(0.71,0.92))中,用等热量PUFA替代SFAs总能量摄入的5%与高尿酸血症几率降低相关。在男性（0.87（0.80，0.94））和所有个体（0.92（0.88，0.98））中，用非海洋PUFA代替SFA也观察到了类似的趋势。敏感性分析显示出与主要分析一致的结果。
结论：较高的n-3PUFA的膳食摄入量，n-6PUFA,洛杉矶,ALA,非海洋PUFA与高尿酸血症风险降低相关。这些结果支持在饮食中用PUFA代替SFA的建议。
结果：根据2003-2015年全国健康与营养调查（NHANES），根据高尿酸血症诊断标准（男性血尿酸>420μmol/L，女性血尿酸>360μmol/L）将所有符合条件的个体分为高尿酸血症组和非高尿酸血症组。采用多因素调整逻辑回归分析膳食PUFA摄入量与高尿酸血症风险之间的关系。对总PUFA及其亚型进行建模，以等热地替代饱和脂肪酸（SFA）和单不饱和脂肪酸（MUFA）。较高的n-3PUFA摄入量，n-6PUFA,亚油酸（LA），α-亚油酸（ALA），非海洋PUFA摄入量与高尿酸血症风险降低相关，调整后的比值比(OR)和95%置信区间(95CIs)为0.77(0.63，0.93)，0.75（0.61，0.92），0.75（0.61，0.91），0.69（0.55，0.87），和0.73（0.59，0.91），分别。在男性(0.69(0.57,0.84))和个体(0.81(0.71,0.92))中,用等热量PUFA替代SFAs总能量摄入的5%与高尿酸血症几率降低相关。在男性（0.87（0.80，0.94））和所有个体（0.92（0.88，0.98））中，用非海洋PUFA代替SFA也观察到了类似的趋势。敏感性分析显示出与主要分析一致的结果。
结论：较高的n-3PUFA的膳食摄入量，n-6PUFA,洛杉矶,ALA,非海洋PUFA与高尿酸血症风险降低相关。这些结果支持在饮食中用PUFA代替SFA的建议。
