Abstract：
Despite its widespread use as a stabilizer across various industries over the past several decades, the health effects of chronic exposure to PFOA are still unclear. We administered PFOA by oral gavage (0, 12.5, 50, and 200 μg/day/mouse, eight groups) to male and female mice for six months. Body weight gain decreased with dose accompanied by increased liver weight, and PFOA altered liver damage-related-blood biochemical indicators and induced pathological lesions, including hepatocellular hypertrophy, cholangiofibrosis, and centrilobular hepatocellular vacuolation. Loss of the Golgi apparatus, formation of lamellar body-like structures, and lipid accumulation were observed in the liver of PFOA-treated mice. We also cohabited five pairs of male and female mice for the last ten days of administration, dosed PFOA to dam up to 28 days after birth, and investigated effects on reproduction and development. The survival rate of pups and the sex ratio of surviving mice decreased significantly at the highest dose. PFOA tissue concentration increased with the dose in the parent mice\'s liver and the pups\' blood and brain. Taken together, we suggest that PFOA primarily affects the liver and reproduction system and that disturbance in lipid metabolism and Golgi\'s structural stability may be involved in PFOA-induced toxicity.
摘要：
尽管在过去的几十年中，它被广泛用作各种行业的稳定剂，长期暴露于PFOA对健康的影响尚不清楚.我们通过口服管饲法给予PFOA（0、12.5、50和200μg/天/小鼠，八组)给雄性和雌性小鼠六个月。体重增加随着剂量的减少而伴随着肝脏重量的增加，PFOA改变肝损伤相关血液生化指标并诱发病理损伤，包括肝细胞肥大,胆管纤维化,和小叶中央肝细胞空泡化。高尔基体的丧失,层状体状结构的形成，在PFOA处理的小鼠的肝脏中观察到脂质积累。在给药的最后十天，我们还同居了五对雄性和雌性小鼠，在出生后28天内给PFOA注射大坝，并研究了对生殖和发育的影响。在最高剂量下，幼崽的存活率和存活小鼠的性别比显着下降。PFOA组织浓度随剂量在亲代小鼠的肝脏和幼鼠的血液和大脑中增加。一起来看,我们认为PFOA主要影响肝脏和生殖系统，脂质代谢和高尔基体结构稳定性的紊乱可能与PFOA诱导的毒性有关。
