Abstract：
This study aims to investigate the environmental fate of irbesartan when subjected to activated percarbonate treatment. The investigation delves into the formation of disinfection byproducts (DBPs) and evaluates their toxicity, and it seeks to draw comparisons with outcomes from treatment with sodium hypochlorite, already characterized in previous findings. The proposed treatment indicates the formation of at least 11 DBPs - eight identified for the first time - which have been isolated by various chromatographic techniques, identified by Nuclear Magnetic Resonance and Mass Spectrometry studies and for which a mechanism has been proposed to elucidate their formation. To evaluate irbesartan\'s biological impact during treatment with sodium percarbonate (SPC), a toxicity study of the DBPs was conducted using Daphnia magna, Aliivibrio fischeri, and Raphidocelis subcapitata, three model organisms. The ecotoxicity was evaluated using the Ecological Structure-Activity Relationships (ECOSAR) computer program and compared with experimental results. Compared to chlorination treatment, a lower mineralization percentage (-43 %) and amount of DBPs at least twice higher were observed. Toxicity assessment highlighted that DBPs formed during SPC treatment were more toxic than those from chlorination. ECOSAR predicted toxicity aligned with experimental findings. Additionally, the DBPs exhibited varying levels of toxicity, primarily attributable to the presence of aromatic and hydroxyl groups in their chemical structure, indicating that SPC treatment is not suitable for treatment of irbesartan polluted waters.
摘要：
本研究旨在研究厄贝沙坦在进行活性过碳酸盐处理时的环境命运。调查深入研究了消毒副产物（DBPs）的形成，并评估了其毒性，它试图与次氯酸钠治疗的结果进行比较，已经在以前的发现中表征。拟议的处理表明形成了至少11个DBP-首次鉴定出8个-已通过各种色谱技术分离。通过核磁共振和质谱研究鉴定，并提出了一种机制来阐明它们的形成。评估厄贝沙坦在过碳酸钠（SPC）治疗期间的生物学影响，使用大型蚤对DBPs进行了毒性研究，费氏弧菌,和头状花序，三个模式生物。使用生态结构-活动关系（ECOSAR）计算机程序评估了生态毒性，并与实验结果进行了比较。与氯化处理相比，观察到较低的矿化百分比（-43％）和DBPs的数量至少高出两倍。毒性评估强调，在SPC处理期间形成的DBPs比氯化产生的DBPs毒性更大。ECOSAR预测的毒性与实验结果一致。此外,DBP表现出不同程度的毒性，主要归因于在它们的化学结构中存在芳香和羟基，表明SPC处理不适用于厄贝沙坦污染水体的处理。
