PDF(Pubmed)
Abstract：
This study aimed to develop Janus-, cross-network-, and coaxial-structured piezoelectric-conductive polymer nanofibers through electrospinning to mimic the piezoelectricity of bone and facilitate the conduction of electrical signals in bone tissue repair. These nanofibers were constructed using the piezoelectric polymer polyvinylidene fluoride, and the conductive fillers reduced graphene oxide and polypyrrole. The influence of structural features on the electroactivity of the fibers was also explored. The morphology and components of the various structural samples were characterized using SEM, TEM, and FTIR. The electroactivity of the materials was assessed with a quasi-static d33 meter and the four-probe method. The results revealed that the piezoelectric-conductive phases were successfully integrated. The Janus-structured nanofibers demonstrated the best electroactivity, with a piezoelectric constant d33 of 24.5 pC/N and conductivity of 6.78 × 10-2 S/m. The tensile tests and MIP measurements showed that all samples had porosity levels exceeding 70%. The tensile strength of the Janus and cross-network structures exceeded that of the periosteum (3-4 MPa), with average pore sizes of 1194.36 and 2264.46 nm, respectively. These properties indicated good mechanical performance, allowing material support while preventing fibroblast invasion. The CCK-8 and ALP tests indicated that the Janus-structured samples were biocompatible and significantly promoted the proliferation of MC3T3-E1 cells.
摘要：
本研究旨在开发Janus-，跨网络-，和同轴结构的压电导电聚合物纳米纤维通过静电纺丝模拟骨骼的压电性，促进骨组织修复中电信号的传导。这些纳米纤维是使用压电聚合物聚偏氟乙烯构建的，导电填料还原了氧化石墨烯和聚吡咯。还探索了结构特征对纤维电活性的影响。使用SEM对各种结构样品的形貌和成分进行了表征，TEM,和FTIR。用准静态d33表和四探针方法评估材料的电活性。结果表明，成功地集成了压电导电相。Janus结构的纳米纤维表现出最好的电活性，压电常数d33为24.5pC/N，电导率为6.78×10-2S/m。拉伸测试和MIP测量显示所有样品的孔隙率水平超过70%。Janus和交叉网络结构的拉伸强度超过了骨膜的拉伸强度（3-4MPa），平均孔径为1194.36和2264.46nm，分别。这些性能表明良好的机械性能，允许材料支持，同时防止成纤维细胞入侵。CCK-8和ALP测试表明Janus结构样品具有生物相容性，并显着促进MC3T3-E1细胞的增殖。
