PDF(Pubmed)
Abstract：
New gelatin methacryloyl (GelMA)-strontium-doped nanosize hydroxyapatite (SrHA) composite hydrogel scaffolds were developed using UV photo-crosslinking and 3D printing for bone tissue regeneration, with the controlled delivery capacity of strontium (Sr). While Sr is an effective anti-osteoporotic agent with both anti-resorptive and anabolic properties, it has several important side effects when systemic administration is applied. Multi-layer composite scaffolds for bone tissue regeneration were developed based on the digital light processing (DLP) 3D printing technique through the photopolymerization of GelMA. The chemical, morphological, and biocompatibility properties of these scaffolds were investigated. The composite gels were shown to be suitable for 3D printing. In vitro cell culture showed that osteoblasts can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-SrHA hydrogel has good cell viability and biocompatibility. The GelMA-SrHA composites are promising 3D-printed scaffolds for bone repair.
摘要：
使用UV光交联和3D打印开发了新型明胶甲基丙烯酰基（GelMA）-锶掺杂的纳米羟基磷灰石（SrHA）复合水凝胶支架，用于骨组织再生，具有锶（Sr）的受控输送能力。虽然Sr是一种有效的抗骨质疏松剂，同时具有抗吸收和合成代谢特性，全身给药时，它有几个重要的副作用。通过GelMA的光聚合，基于数字光处理（DLP）3D打印技术开发了用于骨组织再生的多层复合支架。化学,形态学,并研究了这些支架的生物相容性。复合凝胶被证明适用于3D打印。体外细胞培养表明成骨细胞能在水凝胶表面粘附和增殖,表明GelMA-SrHA水凝胶具有良好的细胞活力和生物相容性。GelMA-SrHA复合材料是用于骨修复的有前途的3D打印支架。
