Abstract:
Aging clocks are predictive models of biological age derived from age-related changes, such as epigenetic changes, blood biomarkers, and, more recently, the microbiome. Gut and skin microbiota regulate more than barrier and immune function. Recent studies have shown that human microbiomes may predict aging. In this narrative review, we aim to discuss how the gut and skin microbiomes influence aging clocks as well as clarify the distinction between chronological and biological age. A literature search was performed on PubMed/MEDLINE databases with the following keywords: \"skin microbiome\" OR \"gut microbiome\" AND \"aging clock\" OR \"epigenetic\". Gut and skin microbiomes may be utilized to create aging clocks based on taxonomy, biodiversity, and functionality. The top contributing microbiota or metabolic pathways in these aging clocks may influence aging clock predictions and biological age. Furthermore, gut and skin microbiota may directly and indirectly influence aging clocks through the regulation of clock genes and the production of metabolites that serve as substrates or enzymatic regulators. Microbiome-based aging clock models may have therapeutic potential. However, more research is needed to advance our understanding of the role of microbiota in aging clocks.
摘要:
衰老时钟是生物年龄的预测模型,来自与年龄相关的变化,如表观遗传变化,血液生物标志物,and,最近,微生物组。肠道和皮肤微生物群调节的不仅仅是屏障和免疫功能。最近的研究表明,人类微生物组可以预测衰老。在这篇叙述性评论中,我们的目的是讨论肠道和皮肤微生物组如何影响衰老时钟,并阐明时间和生物年龄之间的区别。在PubMed/MEDLINE数据库上进行文献检索,关键词为:“皮肤微生物组”或“肠道微生物组”和“衰老时钟”或“表观遗传学”。肠道和皮肤微生物组可以用来创建基于分类法的衰老时钟,生物多样性,和功能。这些衰老时钟中最重要的微生物群或代谢途径可能会影响衰老时钟预测和生物年龄。此外,肠道和皮肤微生物群可以通过时钟基因的调节和作为底物或酶调节剂的代谢物的产生直接和间接地影响衰老时钟。基于微生物组的衰老时钟模型可能具有治疗潜力。然而,需要更多的研究来提高我们对微生物群在衰老时钟中的作用的理解。