PDF(Pubmed)
Abstract：
This article provides an overview of the development, structure and activity of various metal complexes with anti-cancer activity. Chemical researchers continue to work on the development and synthesis of new molecules that could act as anti-tumor drugs to achieve more favorable therapies. It is therefore important to have information about the various chemotherapeutic substances and their mode of action. This review focuses on metallodrugs that contain a metal as a key structural fragment, with cisplatin paving the way for their chemotherapeutic application. The text also looks at ruthenium complexes, including the therapeutic applications of phosphorescent ruthenium(II) complexes, emphasizing their dual role in therapy and diagnostics. In addition, the antitumor activities of titanium and gold derivatives, their side effects, and ongoing research to improve their efficacy and reduce adverse effects are discussed. Metallization of host defense peptides (HDPs) with various metal ions is also highlighted as a strategy that significantly enhances their anticancer activity by broadening their mechanisms of action.
摘要：
这篇文章提供了发展的概述，具有抗癌活性的各种金属配合物的结构和活性。化学研究人员继续致力于新分子的开发和合成，这些分子可以作为抗肿瘤药物来实现更有利的治疗。因此,重要的是获得关于各种化疗物质及其作用方式的信息。这篇综述的重点是含有金属作为关键结构片段的金属药物，顺铂为其化疗应用铺平了道路。本文还着眼于钌配合物，包括磷光钌（II）配合物的治疗应用，强调他们在治疗和诊断中的双重作用。此外,钛和金衍生物的抗肿瘤活性，它们的副作用，和正在进行的研究，以提高其疗效和减少不良反应进行了讨论。具有各种金属离子的宿主防御肽（HDP）的金属化也被强调为通过扩大其作用机制而显着增强其抗癌活性的策略。
