TXNDC5 通过不同内质网应激信号通路调节肝细胞内质网活性的重要作用.
关键词: ATF6 EIF2AK3 ERN1 HSPA5 IRE1a NAFLD PERK TXNDC5 endoplasmic reticulum stress hepatocytes liver palmitic acid thapsigargin tunicamycin
Mesh : Endoplasmic Reticulum Stress Endoplasmic Reticulum Chaperone BiP / metabolism Protein Disulfide-Isomerases / metabolism genetics Signal Transduction Hepatocytes / metabolism Animals Tunicamycin / pharmacology Endoplasmic Reticulum / metabolism Mice Reactive Oxygen Species / metabolism Activating Transcription Factor 6 / metabolism genetics Cell Line Protein Serine-Threonine Kinases / metabolism genetics Heat-Shock Proteins / metabolism genetics Endoribonucleases / metabolism genetics Palmitic Acid / pharmacology metabolism Thapsigargin / pharmacology Humans Non-alcoholic Fatty Liver Disease / metabolism genetics pathology Thioredoxins / metabolism genetics Cell Survival / drug effects
来 源:
DOI:10.3390/ijms25137128
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