母体蛋白质营养不良(MPM)的状态与几种有害影响有关,包括炎症过程和氧化平衡失调,可以促进神经变性。另一方面,众所周知,有氧运动可以促进全身健康益处,对抗多种慢性疾病。因此,我们评估了有氧运动训练(AET)对线粒体生物能学指标的影响,氧化平衡,内质网应激,营养不良幼龄Wistar大鼠前额叶皮质中的神经营养因子。怀孕的Wistar大鼠在怀孕和哺乳期间用含有17%或8%酪蛋白的饮食喂养。在生命的30天,雄性后代分为4组:低蛋白对照(LS),低蛋白训练(LT),正常蛋白对照(NS),和正常蛋白训练(NT)。受训组进行了为期4周的AET,一周五天,每次会议每天1小时。在生命的60天,处死动物,骨骼肌,去除前额叶皮质(PFC)以评估ATF-6,GRP78,PERK和BDNF的氧化代谢标志物和基因表达。我们的结果表明,MPM损害与较高的氧化和网状应激相关的氧化代谢。然而,AET恢复了线粒体生物能学指标的水平,除了促进细胞应激的恢复力。在年轻的Wistar大鼠中,中等强度的AET持续4周,可以充当非药物干预措施,以对抗蛋白质限制的母体饮食的有害影响。
The state of Maternal Protein Malnutrition (MPM) is associated with several deleterious effects, including inflammatory processes and dysregulation in oxidative balance, which can promote neurodegeneration. On the other hand, it is known that aerobic exercise can promote systemic health benefits, combating numerous chronic diseases. Therefore, we evaluate the effect of aerobic exercise training (AET) on indicators of mitochondrial bioenergetics, oxidative balance, endoplasmic reticulum stress, and neurotrophic factor in the prefrontal cortex of malnourished juvenile Wistar rats. Pregnant Wistar rats were fed with a diet containing 17% or 8% casein during pregnancy and lactation. At 30 days of life, male offspring were divided into 4 groups: Low-Protein Control (LS), Low-Protein Trained (LT), Normoprotein Control (NS), and Normoprotein Trained (NT). The trained groups performed an AET for 4 weeks, 5 days a week, 1 h a day per session. At 60 days of life, the animals were sacrificed and the skeletal muscle, and prefrontal cortex (PFC) were removed to evaluate the oxidative metabolism markers and gene expression of ATF-6, GRP78, PERK and BDNF. Our results showed that MPM impairs oxidative metabolism associated with higher oxidative and reticulum stress. However, AET restored the levels of indicators of mitochondrial bioenergetics, in addition to promoting resilience to cellular stress. AET at moderate intensity for 4 weeks in young Wistar rats can act as a non-pharmacological intervention in fighting against the deleterious effects of a protein-restricted maternal diet.