PDF(Pubmed)
Abstract：
The number of people diagnosed with type 2 diabetes is on the increase worldwide. Of growing concern, the prevalence of type 2 diabetes in children and youths is increasing rapidly and mirrors the increasing burden of childhood obesity. There are many risk factors associated with the condition; some are due to lifestyle, but many are beyond our control, such as genetics. There is an urgent need to develop better therapeutics for the prevention and management of this complex condition since current medications often cause unwanted side effects, and poorly managed diabetes can result in the onset of related comorbidities. Naturally derived compounds have gained momentum for preventing and managing several complex conditions, including type 2 diabetes. Here, we provide an update on the benefits and limitations of fenugreek and its components as a therapeutic for type 2 diabetes, including its bioavailability and interaction with the microbiome.
摘要：
全球被诊断患有2型糖尿病的人数正在增加。越来越令人担忧的是，儿童和青少年中2型糖尿病的患病率正在迅速增加，这反映了儿童肥胖负担的增加。有许多与病情相关的风险因素;有些是由于生活方式，但很多都是我们无法控制的,比如遗传学。迫切需要开发更好的治疗方法来预防和管理这种复杂的疾病，因为目前的药物通常会引起不必要的副作用。和管理不善的糖尿病可导致相关合并症的发作。天然衍生的化合物已经获得了预防和管理几种复杂条件的动力，包括2型糖尿病。这里,我们提供了有关胡芦巴及其成分作为2型糖尿病治疗剂的益处和局限性的最新信息，包括其生物利用度和与微生物组的相互作用。
