PDF(Pubmed)
Abstract：
The emotion of disgust protects individuals against pathogens, and it has been found to be elevated during pregnancy. Physiological mechanisms discussed in relation to these changes include immune markers and progesterone levels. This study aimed to assess the association between steroids and disgust sensitivity in pregnancy. Using a prospective longitudinal design, we analyzed blood serum steroid concentrations and measured disgust sensitivity via text-based questionnaires in a sample of 179 pregnant women during their first and third trimesters. We found positive correlations between disgust sensitivity and the levels of C19 steroids (including testosterone) and its precursors in the Δ5 pathway (androstenediol, DHEA, and their sulfates) and the Δ4 pathway (androstenedione). Additionally, positive correlations were observed with 5α/β-reduced C19 steroid metabolites in both trimesters. In the first trimester, disgust sensitivity was positively associated with 17-hydroxypregnanolone and with some estrogens. In the third trimester, positive associations were observed with cortisol and immunoprotective Δ5 C19 7α/β-hydroxy-steroids. Our findings show that disgust sensitivity is positively correlated with immunomodulatory steroids, and in the third trimester, with steroids which may be related to potential maternal-anxiety-related symptoms. This study highlights the complex relationship between hormonal changes and disgust sensitivity during pregnancy.
摘要：
厌恶的情绪保护个体免受病原体的侵害，并且发现它在怀孕期间升高。与这些变化有关的生理机制包括免疫标记和孕酮水平。这项研究旨在评估类固醇与妊娠期厌恶敏感性之间的关系。使用前瞻性纵向设计，我们分析了血清类固醇浓度,并通过基于文本的问卷测量了179名孕妇在孕早期和妊娠晚期的厌恶敏感度.我们发现厌恶敏感性与Δ5途径中C19类固醇（包括睾酮）及其前体水平呈正相关（雄烯二醇，DHEA,和它们的硫酸盐）和Δ4途径（雄烯二酮）。此外,在两个三个月中，与5α/β减少的C19类固醇代谢物呈正相关。在头三个月，厌恶敏感性与17-羟基孕烷醇酮和一些雌激素呈正相关.在妊娠晚期，与皮质醇和免疫保护性Δ5C197α/β-羟基类固醇呈正相关。我们的研究结果表明，厌恶敏感性与免疫调节类固醇呈正相关，在妊娠晚期，可能与潜在的母亲焦虑相关症状有关的类固醇。这项研究强调了怀孕期间荷尔蒙变化与厌恶敏感性之间的复杂关系。
